Biomedical Research Lab Technician (Tyser Lab)

Applications are invited for a Research Technician position in the group of Dr Richard Tyser within the Cambridge Stem Cell Institute (CSCI) based at the Cambridge Biomedical Campus. The Cambridge Stem Cell Institute is an international centre of excellence for stem cell research and regenerative medicine. Scientists in the Institute collaborate to advance our knowledge of various stem cell types and to perform pioneering work in translational research areas, providing the foundation for new medical treatments (www.stemcells.cam.ac.uk).

The Tyser Lab studies how the mammalian heart forms during embryonic development, exploring how the initiation of function occurs and to what extent this defines and influences the progression of subsequent cardiac morphogenesis. We use a combination of different models including primary mouse and human samples as well as in vitro human Pluripotent Stem Cell differentiation (Tyser, Ibarra-Soria et al. Science 2021; Tyser, Mahammadov et al. Nature 20201; Tyser, Miranda et al. Elife 2016). This research will answer questions of fundamental biological importance with clear clinical relevance such as providing new insight into the origins of Congenital Heart Defects (CHD) as well as augmenting cell-based approaches to treat disease.

We are seeking an enthusiastic and dedicated Research Technician to join our research group with prior experience of laboratory-based biological research, and ideally with expertise in handling mice. The successful candidate will support the research team by providing technical assistance, such as aiding in the management of genetic mouse models. As such, the candidate should have good interpersonal and organisational skills, paying close attention to detail. Other responsibilities include a range of tasks to ensure the smooth running of the laboratory, such as ordering and maintaining laboratory supplies, and maintaining and updating protocols and reagent databases. An understanding of the principles of cellular and molecular biology (DNA & RNA extraction, quantitative PCR, molecular cloning) or computational experience would be desirable.

For this position we would welcome applications for part-time/flexible working patterns, including shorter working days.

Responsibilities/duties

• Provide support and technical assistance for research projects. Conduct experimental protocols and techniques from general verbal instructions, prepare and analyse samples, collating results for interpretation by self and others.
• Aid in the management of genetic mouse model colonies and in vivo experiments.
• Maintenance and running of the research laboratory. Instruct research students and staff in the correct application, use and maintenance of equipment, established laboratory procedures and routine experimental techniques. Advise on solutions, sample preparation and analysis methods that could be used, considering time and financial constraints
• Ensure the laboratory has adequate stocks of sterile media, disposables, and equipment. Place orders for consumables, and equipment when required and process delivery notes.
• Liaise with the departmental safety officer to ensure codes of practice and relevant safety regulations are implemented and observed within the research laboratory, carry out risk assessments as well as introduce new staff and researchers to the health and safety procedures within the laboratory.

Please ensure that you outline how you match the criteria for the post and why you are applying for this role on the online Application form.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

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