Research Associate/Senior Research Associate in Novel Recombinant Protein Designs and Production for Red Blood Cell Attachment

Contract Type: Open Ended

Work Hours 35.0 Hours per Week

Weeks per year-Weeks per year: 52.00

The role

A 12-month post-doctoral position in computational design and engineering biology to explore and optimise enzyme attachment to red blood cells for therapeutics. The successful candidate will join the lab of Professor Ashley Toye in the School of Biochemistry at the University of Bristol to work on a 12-month fixed-term project. The Toye lab conducts pioneering research on erythrocytes, erythrocyte biology and erythropoiesis in health and disease, with a strong emphasis on translational science.

What will you be doing?

This position will focus on computational protein design, recombinant protein production, and the exploration of methodologies for attaching enzyme-based therapeutics to red blood cells (RBCs).

You will play a pivotal role in optimising, designing, producing, and characterising novel therapeutic proteins engineered for attachment to RBCs. Building on the lab's recent developments, your work will include producing novel recombinant proteins in bacteria at sufficient yield and quality for downstream applications, potentially including preclinical animal studies.

You should apply if

• You will hold a PhD or be working towards one, and have a background in Synthetic biology, Molecular Biology or Biochemistry or related subject.
• You will have significant knowledge and experience of using computational approaches to design novel synthetic proteins.
• You will also have extensive experience in the production and isolation of recombinant proteins in bacteria for downstream applications and testing.
• You will be a team player who can work independently and collaboratively.
• You will have an interest in commercialisation of research.

Additional information

For informal enquiries please contact Professor Ash Toye via email: Ash.m.toye@bristol.ac.uk 

Contract type: Open Ended with fixed term funding until 31/12/2025

Grade: I or J

Salary: Grade I £37,999 - £43,878 or Grade J £42,632 - £47,874 per annum (depending on experience)

School/Unit: Biochemistry

This advert will close at 23:59 UK time on 02/01/2025

Our strategy and mission

We recently launched our strategy to 2030 tying together our mission, vision and values.

The University of Bristol aims to be a place where everyone feels able to be themselves and do their best in an inclusive working environment where all colleagues can thrive and reach their full potential. We want to attract, develop, and retain individuals with different experiences, backgrounds and perspectives – particularly people of colour, LGBT+ and disabled people - because diversity of people and ideas remains integral to our excellence as a global civic institution.

To apply please click on the ‘Apply’ button above.

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