Laboratory Research Scientist

An exciting opportunity for a motivated research technician/ laboratory research scientist to join Kinases and Brain Development laboratory https://www.crick.ac.uk/research/labs/sila-ultanir at the Francis Crick Institute, London, UK.

Ultanir lab is recruiting a Laboratory Research Scientist (LRS) role. The LRS will collaborate with members of the lab and help with human iPSC cultures, including their maintenance and characterization. She/he will also receive training to assist with mass spectrometry experiments.  

Dr Ultanir’s laboratory focuses on the role of protein kinases in neuronal development and function. Kinases regulate numerous cellular processes by phosphorylating their substrates and altering their function. CDKL5 is a brain enriched serine/threonine kinase. Loss of function mutations of CDKL5 cause a severe neurodevelopmental disorder with early-onset seizures and profound developmental delays, termed CDKL5 deficiency disorder (CDD). Our lab’s aim is to understand the roles of CDKL5 in the brain and to reveal how loss of CDKL5 leads to neuronal pathology.

Key Responsibilities

The role of a Laboratory Research Scientist in the Crick is diverse and rewarding. Typical activities include:

• Collaborating with other lab members on/Assisting other lab members with/ research projects.
• Providing experimental or technical support to other lab members.
• Providing technical expertise/ input for the development, refinement and troubleshooting of relevant methodologies.
• Participating in academic activities, including group meetings and journal clubs, seminars, and scientific meetings.
• Organisation and management of the laboratory

Key responsibilities include but are not limited to:

• Differentiate and maintain iPSC derived neuronal cultures
• Maintain rat astrocyte cultures
• Immunostainings and imaging of neurons in culture.
• Cloning, transfection, viral infections of neurons in culture.
• Perform multi-electrode array recordings and data analysis.

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council, Cancer Research UK, Wellcome, UCL, Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

• If you are interested in applying for this role, please apply via the 'Apply' button.
• The closing date for applications is 24/11/24

All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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