Location: | Birmingham |
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Salary: | £41,421 Grade 7 |
Hours: | Full Time |
Contract Type: | Fixed-Term/Contract |
Placed On: | 13th November 2024 |
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Closes: | 27th November 2024 |
Job Ref: | 104889 |
Salary: As this vacancy has limited funding the maximum salary that can be offered is Grade 7, salary £41,421
Contract Type: Fixed Term contract up to January 2028
Role Summary
We have an exciting opportunity for a Postdoctoral Research Fellow to join our vibrant multidisciplinary research team in the Department of Metabolism and Systems Science (MSS) and Centre of Membrane Proteins and Receptors (COMPARE) of the University of Birmingham.
This post, funded by the UKRI-Medical Research Council (MRC) for up to 3 years, is to investigate the fundamental cellular and molecular mechanisms that control storage and release of fatty acids in adipocytes in the context of obesity-related metabolic disorders. This project builds on our preliminary results that free fatty acid receptors 2 and 4 (FFA2/4), members of the G protein-coupled receptor (GPCR) family, are located and function inside cells close to lipid droplets to sense locally released fatty acids and inhibit lipolysis.
Main Duties
Working as part of a multidisciplinary team and in collaboration with Professor Graeme Milligan, University of Glasgow, and Professor David Hodson, University of Oxford, you will utilise state-of-the-art cell signalling, pharmacology and advanced imaging techniques with innovative cell and mouse disease models to elucidate the underlying mechanisms and physiological relevance of this novel potential modality of ‘intracrine’ FFA2/4 signalling.
This is an opportunity for a highly motivated Postdoctoral Research Scientist to conduct basic research with potential for pre-clinical translation. The postholder will be responsible for clarifying the organisation of FFA2/4 signalling nanodomains associated with lipid droplets using cell signalling and advanced microscopy (super-resolution, CLEM, etc.) in vitro, its physiological relevance and its potential exploitation for the therapy of metabolic disorders. They will have access to state-of-the-art equipment and facilities for cell signalling, advanced microscopy and image analysis of the COMPARE Advanced Imaging Facility.
Person Specification
Informal enquiries can be made to Prof. Davide Calebiro, email: d.calebiro@bham.ac.uk.
To download the full job description and details of this position and submit an electronic application online please click on the 'Apply' button above.
Valuing excellence, sustaining investment
We value diversity and inclusion at the University of Birmingham and welcome applications from all sections of the community and are open to discussions around all forms of flexible working.
Closes: 27/11/2024
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