Senior Laboratory Research Scientist

The successful candidate will join the MANIFEST programme within the Cancer Dynamics research group and will work closely with the Flow Cytometry Science Technology Platform (STP), providing advice, training, and expertise in a range of techniques to analyse human cancer specimens for translational research within the MANIFEST platform.

Their time will be spent in the lab, with a primary responsibility for performing multi-colour flow cytometry, cell sorting, and optimiszing and performing single-cell dissociation from different tissue types, including samples that have been fixed for a prolonged time. This will include the development and optimisation of novel protocols to handle different input substrates, antibody panel optimization and high-parameter flow cytometry assays using advanced cytometers, requiring collaboration with key industry partners to develop future assays. Whilst the primary responsibility of the role is to support the MANIFEST Flow Cytometry STP, additional responsibilities will include data acquisition, analysis, and general lab organisation/administration.

Key Responsibilities

• Exemplifying and maintaining standards for the Flow Cytometry STP
• Conducting experimental work autonomously and by own initiative as agreed with the Flow Cytometry STP and Programme Lead
• Operating as a technical specialist in flow cytometry techniques, including high-dimensional flow cytometry, cell sorting and single-cell dissociation
• Interacting with and consulting collaboratively with researchers
• Actively supporting and training team members to develop their skills and promote collective success
• Using knowledge to build on existing methodologies and innovate through identification, assessment, and development of new technologies, to expand the capabilities of the platform under the guidance of the Flow Cytometry STP
• Supporting and contributing to existing projects by effectively and efficiently performing established techniques
• Contributing to the day-to-day operations to ensure the laboratory runs as efficiently as possible

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council, Cancer Research UK, Wellcome, UCL, Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

• If you are interested in applying for this role, please apply via the 'Apply' button.
• The closing date for applications is 21/01/2025
• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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