Postdoctoral Research Associate

Location: Department of Biology, South Parks Road, Oxford OX1 3SY

We are seeking a Postdoctoral Research Associate to work on a BBSRC grant. The research topic is ‘Elucidating the role of the CHLORAD machinery in chloroplast protein degradation’.

You will conduct ground-breaking research on the degradation of chloroplast proteins by the ubiquitin-proteasome system (UPS), focusing on how this is implemented to regulate the chloroplast protein import machinery. Our previous work identified a ubiquitin E3 ligase, termed SP1, in the chloroplast outer membrane that regulates chloroplast protein import by triggering the UPS-mediated degradation of import machinery components; and showed that SP1 cooperates with several other components in a proteolytic pathway termed CHLORAD (chloroplast-associated protein degradation). This project will elucidate the functions of the CHLORAD system in fine molecular detail.

Responsibilities include planning, troubleshooting, and expertly executing the research work involved in this project. You will present and discuss project data in the context of the relevant literature at lab meetings and contribute to the daily organisation and management of the research laboratory. You will analyse and prepare data and contribute to the preparation of manuscripts for publication, and research grant applications. Part of the role will also be to supervise research students and other junior researchers in the research group.

The successful applicant will hold, or be close to completion of, a PhD/DPhil and relevant experience. You will have experience of protein biochemistry and molecular biology, including membrane protein analysis. You will possess the following: high motivation with intellectual curiosity and rigour; ability to work independently and manage multiple tasks; ability to assimilate and evaluate the relevant literature and its implications; and willingness and ability to communicate with colleagues and to assist their work. You will have statistical and data analysis skills relevant to the project and the ability to present data to colleagues and non-specialist audiences. The ability to write effectively is essential.

Informal enquiries should be directed to Paul Jarvis at paul.jarvis@biology.ox.ac.uk

The University of Oxford is committed to equality and valuing diversity. All applicants will be judged on merit, according to the selection criteria.

This post is full time and available from 1 January 2025 until 1 May 2026.

The closing date for applications is 12.00 noon on Friday 15 November 2024, interviews are likely to be scheduled for late November 2024.

Applications for this vacancy are to be made online via our e-recruitment system, and you will be required to upload a supporting statement and CV as part of your online application.

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