Research Associate in Multimodal Neuroimaging and Physiological Modelling

Job description:

This is a 4 year fixed term opportunity for a motivated post-doctoral MRI physicist to work on a Wellcome Trust funded neuroimaging grant. The project centers on the novel application of hyperpolarised xenon for brain oximetry. Using multi-modal imaging methods and animal models this project seeks to understand the application of  hyperpolarised xenon to detect early signs of brain diseases associated with the cerebral vasculature (Atherosclerosis, SVD, Alzheimers). There is a clear route to human translation as these methods are already used in human research. Rigorous physiological validation of the method is the core aim. This role is not limited to Sheffield, there is opportunity to travel to London and collaborate with scientists at the Centre for Advanced Biomedical Imaging, UCL and beyond.

This role offers a chance to contribute to cutting-edge pre-clinical neuroimaging research using a 7T Bruker MRI scanner. You will acquire and analyse data, optimise acquisition parameters for arterial spin labeling and chemical shift imaging with support of existing team members. You will set up real-time image processing to high quality data collection.

The opportunity for bold, discovery science is how to interpret the data in the context of previous research, first principles of MRI physics and experimental physiology. Working closely with the new PI Isabel Christie, you will acquire hypothesis-driven data. Building upon established tracer kinetic models and prior research at Sheffield, you will tailor image processing methods to derive the value of this data to diagnose deficits of gas exchange and blood brain barrier physiology.

The University of Sheffield is a remarkable place to work. Our people are at the heart of everything we do. Their diverse backgrounds, abilities and beliefs make Sheffield a world-class university.

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