Postdoctoral Researcher - Myeloid Leukaemia

Are you an enthusiastic and motivated Postdoctoral Researcher with experience in blood cancer research?

The Oxford Ludwig Institute for Cancer Research has an exciting chance for a Postdoctoral Researcher to join the groups of Professors Xin Lu and Stefan Constantinescu. This position offers a unique opportunity to lead cutting-edge projects at the intersection of leukaemia progression and treatment, oncogenic effects of p53 mutants, on leveraging activation of non-mutated p53 or re-activation of p53 mutants in cancer.

You will be responsible for designing and leading an original research project to investigate how wild type and mutant p53 impact or drive secondary acute myeloid leukaemia and how p53 pathway interacts with inflammatory signals and epigenetics alteration during progression of MPNs to sAML. You will operate laboratory equipment used for all aspects of cell/molecular biology/biochemistry, and interpret results and present them to senior members of the groups. Other duties will include performing original research using biochemical assays, supervising and training junior staff in advanced genomics, and managing your own academic research and administrative activities.

It is essential that you hold a PhD/DPhil (or close to completion) in in molecular biology, biochemistry, cancer research, or a related life science field, and have a background in signalling, molecular haematology, molecular biology. You will have experience working with in vivo/in vitro experimental models, and a working knowledge of the p53 pathway. It is also essential you are able to organise and prioritise work efficiently whilst delivering results to the required standard and to an agreed schedule.

Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience.

This position is offered full time on a fixed term contract for 36 months and is funded by Ludwig.

Only applications received before 12 midday on 4 April 2025 will be considered. Please quote 178747 on all correspondence.

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