Research Associate - Pellegrini Group (Fixed Term)

Applications are invited for a Research Associate position in the laboratory of Professor Luca Pellegrini, in the Department of Biochemistry, University of Cambridge.

Work in the laboratory is focused on elucidating the structural basis for eukaryotic DNA replication (Rzechorzek et al, NAR, 2020; Evrin et al, EMBOJ, 2018; Villa et al, Mol Cell, 2016; Simon et al, Nat Comm, 2016; Simon et al, Nature, 2014) and associated DNA repair processes (Hanthi et al, Mol Cell, 2024; Appleby et al, Nat Comm, 2023; Lerner et al, EMBOJ, 2020; Brouwer et al, EMBOJ, 2018).

The aim of the project is to elucidate key molecular mechanisms of DNA synthesis by the human replisome, the dynamic multi-protein ensemble responsible for duplicating chromosomal DNA before cell division. To achieve this goal, the successful candidates will use a multi-disciplinary approach that includes preparative biochemistry of multi-protein complexes, protein engineering and state-of-the-art biophysical and structural techniques.

Successful candidates will hold a PhD in Biochemistry, Biophysics or Molecular Biology.

They must have a track record in conducting internationally competitive research, including peer-reviewed publications as first author. The ideal candidate will combine an ability to work independently and to fit in well in a team. Above all, they will be enthusiastic about pursuing fundamental research and be highly motivated to succeed professionally.

Expert knowledge of modern methods of preparative biochemistry and/or of quantitative biophysical methods is required. In particular, expertise in the following techniques is essential:

- Insect-cell protein expression and purification

- Biochemical assays for nucleic-acid enzymes.

Additionally, knowledge of structural techniques such as cryo-EM would be an advantage.

Applicants should submit a CV with list of relevant publications, a cover letter explaining why they are suitable for the position and contact information for at least two referees.

Fixed-term: The funds for this post are available until 31st May 2026, in the first instance.

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