Research Assistant/Associate

We have an exciting opportunity for a Research Assistant/Associate to contribute to/make a leading contribution on an EPSRC Programme Grant which aims to engineer an in vitro bone marrow niche to control stem cell regulation, metastatic evolution and cancer dormancy. Leukaemia, kills > 300,000 people per year, globally.

This project aims to understanding the steps involved in leukaemia transformation using advanced hydrogel systems to study normal haemopoietic stem cells (HSCs), pre-leukaemic HSCs harbouring clonal haematopoiesis of indeterminate potential (CHIP) mutations and leukaemic stem cells (LSCs). In particular, this project will focus on cell-to cell interactions and how the architecture of the bone marrow niche is remodelled during malignancy. LSCs dormancy and chemoprotective properties of the bone marrow niche will be areas of interest.

This project will involve validating the bone marrow niche model, testing chemotherapeutic drugs, advanced Brillouin-confocal microscopy and performing biological assays to characterise normal, pre-malignant and malignant samples, working with Professor Helen Wheadon and Professor Mhairi Copland.

The successful candidate will also be expected to help manage and direct this work package and contribute to the formulation and submission of research publications.

This position is full time and funded until 4 February 2029.

Informal enquiries should be directed to Professor Helen Wheadon Helen.Wheadon@glasgow.ac.uk

For the full job description and to apply online: https://my.corehr.com/pls/uogrecruit/erq_jobspec_version_4.jobspec?p_id=159892

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