Research Associate: Computer Simulations of Chromatin Phase Transitions x 2 (Fixed Term)

Fixed-term: The funds for this post are available for 2 years in the first instance.

We are seeking two ambitious and talented postdoctoral research associates to join our team to develop new computational approaches to study chromatin phase transitions at sub-molecular resolution within the ERC-funded project ChromatinDroplets. This is an exciting opportunity to contribute to our goal of understanding the synergistic relationship between multi-component biomolecular condensates, chromatin structure, and gene regulation.

The successful candidate will join the research group led by Prof. Rosana Collepardo (collepardolab.org) based at the Departments of Chemistry and Genetics, University of Cambridge. The Collepardo group develops theoretical methods and multiscale computational models to investigate physical and molecular mechanisms that regulate the organization of biomolecules, including chromatin, inside cells (Joseph et al. Nat Comp Scie, 2021; Garaizar et al., PNAS, 2022; Farr et al., Nat Comms, 2021; Krainer/Welsh/Joseph, Nat Comms, 2021; Espinosa et al. PNAS 2020). Most of our projects are done in collaboration with experimentalists.

We are an interdisciplinary and diverse group of theoretical chemists, physicists, and biologists from many different nationalities and a balanced gender representation. We take pride in our commitment to fostering an inclusive and diverse research culture that celebrates the unique talents of everyone and provides them with equal opportunities regardless of their ethnicity, race, gender, gender identity, sexual orientation, nationality, religion, disability or any other protected characteristic.

The starting date is flexible but preferably around September 2024.

The project involves developing new multiscale models and simulation algorithms to investigate the molecular mechanisms that dictate the behaviour of chromatin inside multi-component condensates and how these are modulated by non-equilibrium phenomena in the nucleus.  The position allows considerable flexibility in research topics within this main theme.

Essential requirements for the candidate include: (1) holding (or about to hold) a PhD/DPhil in Physics or Chemistry, or a closely related field, with a strong interest in biological systems, (2) having strong experience in modelling and simulations of chromatin organization and/or biomolecular phase transitions, (3) have extensive demonstrable experience with LAMMPS and/or OpenMM, (4) have experience in developing or applying coarse-grained models, polymer models, and/or in developing and applying Molecular Dynamics and/or Monte Carlo simulations to biomolecular systems or condensed matter systems.

The role holders' responsibilities will include carrying out their research in computer simulations and statistical mechanics of chromatin phase transitions. Related tasks will include collaborating in the preparation of reports and journal articles, presenting papers at conferences and workshops, representing the group at meetings and seminars, and co-supervising graduate students.

To apply online for this vacancy and to view further information about the role, please click on the apply button above..

Please send applications in the following format: 1) a CV, including full details of all University courses taken to date, with grades (if available) and a publication record (if available); 2) the names and contact details of two academic referees; 3) a cover letter explaining why you wish to be considered for this role, how you match the criteria for the post, and listing your research experience to date.

Informal enquiries can be addressed via email to Prof. Rosana Collepardo rc597@cam.ac.uk

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