Research Associate (Fixed Term)

*Limit of tenure applies - The funds for this post are available until 30th March 2028 in the first instance*

The Institute of Metabolic Science at the University of Cambridge is pleased to invite applications for a Postdoctoral Research Associate position to work with Prof Giles Yeo and Dr Loraine Tung. This role is supported by an industrial collaboration grant from AMGEN, a global leader in pharmaceutical innovation. The successful candidate will explore the molecular and cellular mechanisms driving the weight-loss effects of MariTide, a groundbreaking anti-obesity therapeutic currently in Phase 2 clinical trials.

We are looking for a highly skilled and motivated cell biologist with demonstrated expertise in GPCR biology, particularly in G-protein coupling analysis and the use of miniBRET assays to study receptor turnover and signalling dynamics. Experience with CRISPR-Cas9 gene editing and/or human induced pluripotent stem cell (iPSC) culture is highly desirable. Additionally, an aptitude for bioinformatics, particularly in spatial transcriptomics analysis, would be advantageous.

You will be expected to:

- Run a program of research investigating the molecular and cellular impact of MariTide on a number of human neuronal cell models, including those derived from iPSCs;

- Assist in the analysis of spatial transcriptomic data of brains from mice treated with MariTide;

- Present research work and data within the Institute, nationally and internationally and to prepare and submit research for publication in peer-reviewed journals

- Assist in providing instruction to graduate students and other members of the research group in the standard molecular biology/biochemistry techniques and cellular imaging techniques

- Assist the Principal Investigator in preparation of manuscripts and proposals/applications to funding bodie

To be considered for this position, you must have:

- a Ph.D. in cell biology or biochemistry, or a related discipline with demonstrated expertise in GPCR biology

- extensive research experience in a broad range cell biology techniques such as luminescent assays, neuroscience assays, immunoassays, immunostaining, and microscopy

- a degree of understanding of mammalian neurobiology

- presentation skills backed up by a record of national and/or international presentations

- excellent interpersonal skills including ability to work effectively within a team

- the ability to impart knowledge and skills to graduate students and other members of the research team including graduate students

- the ability to troubleshoot experiments and for the development of novel research tools and platforms

- excellent organizational skills including ability to organize and participate in collaborative research initiatives and projects

Applicants must have (or be close to obtaining) a PhD. 

Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will initially be appointed as a Research Assistant (Grade 5, Point 38 £34,132) moving to Research Associate (Grade 7) upon confirmation of your PhD award.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Closing date: 31st March 2025

Interview date: Week Commencing 7th April 2025

Please quote reference RG45268 on your application and in any correspondence about this vacancy.

Advert information