Postdoctoral Project Research Scientist

About the role… 

Lung cancer remains one of the most pressing public health concerns worldwide, demanding innovative research to address its complexities and challenges. This project seeks to advance our understanding of immunogenic mutations—genomic alterations within cancer cells that result in the production of tumour-specific antigens (neoantigens). Predicting neoantigens in lung cancer involves computational modelling to analyse somatic mutation data, along with transcriptomic and proteomic profiles, to forecast which mutations could produce immunogenic peptides capable of being presented on major histocompatibility complex (MHC) molecules. This project will leverage next-generation sequencing (NGS) data from the TRACERx study to monitor the evolutionary trajectories of lung tumours at multiple time points and in different spatial regions, identifying which mutations are likely to produce neoantigens over time and how these evolve under therapeutic pressure. 

To this end, we are seeking applications from candidates with a creative approach to research with computational competencies to work in a lab with an enviable reputation of producing papers of the highest quality.   

What you will be doing… 

As a PPRS at the Crick, you will: 

• Work on a European project, working within the multi-disciplinary team of clinicians, bioinformaticians and bench scientists in the Swanton lab, and collaborating with groups at the Francis Crick Institute and beyond, including academic and industry partners  
• Drive the project forward using relevant computational approaches  
• Keep up to date with the relevant literature in the field of cancer biology and machine learning  

About you…  

You will bring… 

• PhD in cancer biology / computational biology or other relevant discipline  
• Good knowledge and experience in at least one of the following: cancer biology / cancer immunology / genomics   
• Technical qualifications: expertise in common programming languages such as R or Python  

To see the complete job description, click here. 

For more about team/Group Leader click here. 

About Working at the Crick… 

Our values  

• We are bold. We make space for creative, dynamic and imaginative ideas and approaches.
• We are open. We’re highly collaborative and interactive. Our activities are visible to the outside world. 
• We are collegial. We show respect for one another and work cooperatively. 

We believe that diversity and inclusion are essential to driving innovation and scientific discovery. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We'll make reasonable adjustments if you need them - just let us know when you apply. If you need assistance with applying, please email: nicola.gyte@crick.ac.uk

To find out more about life at the Crick click here.

What will you receive?  

• Visas:
  • The Crick offers funding for those requiring a visa to work in the UK.
• Generous Leave:
  • 28 days of annual leave, plus three additional days over Christmas and bank holidays. 
• Pension Scheme:
  • Defined contribution pension with employer contributions up to 16%. 
• Health & Well-being: 
  • 24/7 GP consultation services. 
  • Occupational and mental health support services. 
• Work-Life Balance: 
  • Back-up care for dependents. 
  • Childcare support allowance. 
• Perks: 
  • Subsidised on-site restaurant, discounted gym memberships, bike-to-work scheme. 

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