Research Fellow (109970-1224)

Location: University of Warwick Campus, Coventry

Duration: Ending 05 January 2028

About the Role  

For informal enquiries, please contact Orkun Soyer (Professor) at o.soyer@warwick.ac.uk.

There is funding to appoint a Research Fellow for up to 36 months. The duration may need to be shortened up to a maximum of 35 months depending on the starting salary of the successful candidate. Appointments are subject to approval from the Leverhulme Trust.

We are looking to hire a postdoctoral researcher to work on a Leverhulme Trust funded project within the research group of Dr. Orkun Soyer. This project is a collaboration between Soyer’s group at the University of Warwick and Prof. Wenying Shou at the University College London. The overall aim of the project is to understand the role of metabolic co-substrates (and in particular NADH) in the regulation of the respiration – fermentation flux switch. Our work combines mathematical modelling and experimentation in yeast and this post will focus on the experimental work at the single-cell level.

Candidates should have a background in quantitative biology, cell biology, biochemistry, biophysics, engineering, or microbial physiology. Candidates should have experience in one or multiple of the key quantitative techniques such as fluorescent microscopy, image analysis, microfluidics, metabolomics, and transcriptomics. They should have experience in working with yeast or more broadly in cell culture and in experiment design and conduct. Ideal candidates should be familiar with any one or multiple of these, or similar, techniques.

KEYWORDS:  – [quantitative biology, cell metabolism, system dynamics, fluorescent microscopy, cell physiology]

What scientific question will you investigate?  / Outline of the project aims

This project will focus on the respiration-fermentation switch seen across microbial and mammalian cells, including cancer cells. The regulatory basis of this switch remains elusive. With this project, we will specifically test predictions from our ongoing mathematical modelling work, where we focus on the role of co-substrate dynamics – particularly NADH dynamics – in regulating fluxes at metabolic branch points.

About the research group

Soyer group at the University of Warwick works in the broad field of quantitative biology, with a focus on cell metabolism and metabolic interactions among cells. Further information is found on the group website: https://warwick.ac.uk/fac/sci/lifesci/research/osslab/

As part of the Soyer group, the candidate will become part of a vibrant quantitative biology community at Warwick and benefit from excellent facilities. This includes a two-photon microscope with lifetime capability that will be heavily used for this project, as well as -omics, microfluidics, and robotics facilities.

We and the wider University of Warwick environment offer substantial opportunities for professional development including regular opportunities to attend international conferences.

CLOSING DATE: Wednesday 01 January 2025 at 11.55 pm

Full details of the duties and selection criteria for this role can be found in the vacancy advert on the University of Warwick's jobs pages. You will be routed to this when you click on the Apply button.

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