Senior Bioinformatician (Imaging)

Short summary

An exciting Senior Bioinformatician post is available for MANIFEST (“Multiomic ANalysis of Immunotherapy Features Evidencing Success and Toxicity”), a newly formed ambitious multi-stakeholder consortium involving academic, industry and NHS partners to deliver deep multiomic profiling for patients with cancer undergoing immunotherapy. The MANIFEST consortium represents a diverse group of UK-wide experts in cancer research and clinical care comprising major NHS trusts, academic institutes and universities, and industry partners. This grant is funded by the UK Office of Life Sciences and the Medical Research Council

The post-holder will work under the supervision of Prof. Samra Turajlic (Francis Crick Institute) to quantify dynamic changes in cellular populations as tumours evolve over space and time from primary through to metastatic disease. The primary duty of the post-holder will be to optimise existing algorithms for the analysis and interpretation of multiplex immunofluorescence imaging data, including cell segmentation and quantification and identification of individual cell types within the tumour microenvironment as well as their spatial and social organisation.

Key Responsibilities

Include but not limited to:

• To work within the bioinformatics team of the Turajlic lab, and collaborating groups at Francis Crick Institute and beyond, including academic and industry partners.
• To optimise image analysis platforms capable of answering research questions associated with the response to cancer immunotherapy. To provide expert analysis of high-throughput spatial imaging and spatial omics data.
• To develop and/or optimise methodologies and techniques to address analysis challenges and implement tools, pipelines and data resources in relation to these technologies.
• To provide consultation and communication in data analysis, data mining, and statistics for analysis of biological data.
• To analyse large-scale multi-region imaging data.
• To provide statistical support to other team members.
• To liaise and coordinate between project collaborators

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council, Cancer Research UK, Wellcome, UCL, Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

• If you are interested in applying for this role, please apply via the ‘Apply’ button above.
• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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