Research Fellow in Ca2+ Signalling

About us

Biosciences is one of the world’s foremost centres for research and teaching in the biological sciences and one of the largest Divisions within UCL, undertaking a significant amount of research and teaching. The Division has a diverse portfolio addressing all areas of biology from protein interactions to cell function, organism development, genetics, population studies and the environment. Computational modelling approaches are frequently used alongside experimental research programmes and much of our research crosses traditional boundaries, including the relationship of biodiversity to the health of the planet. Activity is underpinned by high calibre science technology platforms and state of the art equipment. Educational activity includes a range of undergraduate programmes, an expanding number of Masters Programmes and a substantial number of postgraduate research students.

This is an exciting opportunity to join the Patel Lab (https://profiles.ucl.ac.uk/9779-sandip-patel/publications) based in the Department of Cell and Developmental Biology (https://www.ucl.ac.uk/biosciences/cell-and-developmental-biology). The aim of the project is to investigate the relationship between endo-lysosomal two-pore channels and novel NAADP-binding proteins in the control of cellular Ca²⁺ signals.

About the role

The main purpose of this position is to perform cutting-edge research using molecular, biochemical and cellular approaches coupled with computational methods to better understand the molecular basis of Ca²⁺ release evoked by the second messenger NAADP. It builds on the recent identification of small molecule NAADP mimetics and the NAADP receptors, JPT2 and Lsm12. See the attached JD for the references for background information.

Salary is £43,124 per annum inclusive of London Weighting.

Interview Date(s) are scheduled for January 2025.

This is an open-ended contract with a funding end date of 30/06/2026 in the first instance.

Research Fellows - 'Appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at Grade 6B (salary £34,502 - £36,348 per annum) with payment at Grade 7 being backdated to the date of final submission of the PhD Thesis.'

This appointment is subject to UCL Terms and Conditions of Service for Research and Professional Services Staff. Please visit https://www.ucl.ac.uk/human-resources/conditions-service-research-teaching-and-professional-services-staff for more information.

A job description and person specification can be accessed at the bottom of this page.

If you need reasonable adjustments or a more accessible format to apply for this job online or have any queries about the application process, please contact Biosciences staffing at .

About you

• You must have a relevant PhD Qualification.
• You must have experience in relevant molecular cell biology techniques (molecular biology, biochemical assays, cell culture, microscopy).
• Knowledge of computational methods and/or adenine-based signalling would be an advantage.
• You will assist the team in the development, planning and delivery of research funded by the BBSRC.
• You will be expected to produce independent and original contributions to the development of the project.
• You will be expected to help identify further funding opportunities.
• In addition to developing and conducting the research, you will communicate results as scientific papers and in scientific presentations at local, national, and international conferences.

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