Research Fellow

The UCL Cancer Institute (https://www.ucl.ac.uk/cancer/) is the hub for cancer research at University College London, one of the World's leading universities. The Institute draws together over 400 talented scientists who are working together to translate research discoveries into developing kinder, more effective therapies for cancer patients.

The aim of this post is to develop the first immunocompetent mouse model of human T-ALL by: 1) generating synthetic T-ALL with defined genetic lesions in human haematopoietic stem cells (HSCs), 2) engrafting HSCs from the same donor into immunodeficient mice for humanised haematopoiesis, 3) introducing the synthetic T-ALL.

About the role

This role will be based in the Maciocia laboratory at UCL Cancer Institute, with additional supervision from Professor Marc Mansour. The postholder will further develop a model of synthetic human T-ALL and for the first time apply this in an immunocompetent setting. The post will involve molecular cloning, lentiviral production, HSC isolation and manipulation, complex analysis using flow cytometry, RNA-seq and other tools. There will a large component of murine work involved in establishing, validating and testing the model. There is a substantial focus on development and testing of new immunotherapies for T-ALL, with a focus on CAR-T.

The post is funded for 24 months in the first instance.

Salary offered for this post will either be on grade 7: £42,099 - £50,585 per annum or grade 8: £51,474 - £60,521 per annum inclusive of London Allowance.

Your application should include a CV and a Cover Letter: In the Cover Letter please evidence the essential and desirable criteria in the Person Specification part of the Job Description. (By including a Cover Letter, you can leave blank the 'Why you have applied for this role' field in the application form, which is limited in the number of characters it will allow.)

The successful candidate will have a PhD in related subject and a 2.1 BSc in biomedical sciences or a related subject.

They will show a strong commitment to the lab mission and embody its values through excellent collaborative interpersonal skills with an ability to work cooperatively in a multidisciplinary setting. Further, excellent communication skills and the ability to work well in a multidisciplinary team and to train juniors are essential. The post-holder will be expected to have the ability to assist other members of the lab, supervise MSc and PhD students, collaborate with external research groups, as well as contributing to the organisation and smooth operation of the lab.

Appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at Research Assistant Grade 6B £38,357- £41,005 (salary per annum) with payment at Grade 7 being backdated to the date of final submission of the PhD t hesis.

https://www.ucl.ac.uk/equality-diversity-inclusion/

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