Senior Laboratory Research Scientist

Location: The Francis Crick Institute, Midland Road, London

Short summary

The Partnership

The newly funded Molecular Glue Discovery Partnership represents an exciting new research partnership between the Francis Crick Institute and Imperial College working in close collaboration with AstraZeneca, to develop systematic approaches to exploit endogenous protein degradation pathways to target un-druggable disease-relevant proteins or protein complexes.  

We are seeking an enthusiastic SLRS researcher (ideally with postdoctoral experience) to help create, validate and execute proximity-based cell screens and cell-free assays for the identification and validation of molecular glue degraders. The large majority of intractable targets may only be correctly folded in cells where they bind to other proteins, nucleic acids, metabolites, etc. to exercise their function(s). Such targets require development of high-throughput screens in cellular or appropriate cell free reconstituted environments; in addition, molecular glue hits in primary screen are expected to be low affinity, requiring the development of sensitive cellular and cell-free screening assays. 

This position will require you to collaborate with researchers to co-develop assays, plan and conduct large-scale screens balancing a number of distinct projects at different levels of development simultaneously. This is an opportunity to use your accumulated biology knowledge and curiosity about other areas of biology as well as your skills at the bench and desire to try new things towards creating the most informative and valuable research data possible.  You will work with highly experienced colleagues and collaborators in an institute that values discovery without boundaries.

Key Responsibilities

These include but not limited to;

• Running multiple screening projects simultaneously
• in vitro and cellular assay development
• Ensuring your domain specific knowledge is sufficient to create optimal assays
• Managing workload, co-ordinating and maintaining a productive dialogue with all partnership members
• Keep up to date with the activities in the Partnership to anticipate future needs 

About us

The Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council, Cancer Research UK, Wellcome, UCL, Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy. 

• If you are interested in applying for this role, please apply via our website.
• The closing date for applications is 3/11/2024
• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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