PhD Studentship: Platelet (dys)function in early pathophysiology of neurodegeneration

This project provides an annual stipend of £19,237. 

Project advert

This PhD project explores how platelet function, which triggers blood clotting, contributes to early neurodegenerative processes, focusing on mild cognitive impairment (MCI) and potential progression to dementia. Recent findings from our research group indicate the direct effects of platelet reactivity on neurovascular function and cognitive performance in older adults. Building on emerging evidence, this research will integrate in vitro experiments with in vivo neurovascular physiology assessments in patients with MCI.

The studentship offers a comprehensive interdisciplinary approach to studying neurodegeneration. You will use advanced imaging techniques, including functional MRI and Near-Infrared Spectroscopy, to investigate neurovascular changes, providing insights into cerebral blood flow and oxygen metabolism during cognitive tasks. Additionally, innovative in vitro models will be used to study the direct effects of platelets on neurovascular cells, examining platelet interactions with brain endothelial cells, astrocytes, and neurons. By integrating these methodologies, this research aims to identify early biomarkers of neurodegeneration and suggest new therapeutic targets.

You will also work with an inclusive interdisciplinary team of world leaders with access to state-of-the-art facilities.

Project aims and objectives

The aims are to investigate the role of platelet function in the early stages of neurodegeneration, focusing on mild cognitive impairment (MCI). By achieving the following objectives, this research will provide a detailed understanding of the potential role of platelets in early neurodegenerative processes, paving the way for novel preventive and therapeutic strategies.

Objectives:

• Assess the behavioural and cognitive implications of elevated platelet reactivity:
• Identify the physiological components of neurovascular function impaired in early neurodegeneration:
• Explore the direct impact of platelets on neurovascular function:

Specific requirements of the candidate

Essential Criteria: 

• A first class or upper second class (2:1) degree (or equivalent) in a relevant discipline such as biology, cognitive neuroscience, psychology, physiology, sport and exercise physiology, physics or mathematics. Strong candidates with sports science, physiotherapy, radiography or sports psychology related degrees will also be considered. 
• An ability to critique and analyse scientific evidence, methodology and data.
• Strong interpersonal, communication and organisational skills.
• Motivation and passion for the study of integrative physiology.

Desirable Criteria:

• MSc or Research Masters in a relevant discipline such as biology, cognitive neuroscience, psychology, physiology.
• Experience in interdisciplinary research.
• Coding and programming experience (e.g. Python, MATLAB, R).
• Image data analysis or relevant signal processing skills.
• MRI imaging experience at 3 Tesla field strengths.
• Phlebotomy training and experience.
• Cell biology experience or experience of using in vitro models.

How to apply

Interested applicants should contact Dr Gabriella Rossetti (g.rossetti@mmu.ac.uk)for an informal discussion. APCs will be £5k p.a.

To apply you will need to complete the online application form for a full-time PhD in Human Neuroscience (or download the PGR application form).

You should also complete the PGR thesis proposal /Narrative CV (supplementary information) form addressing the project’s aims and objectives, demonstrating how the skills you have maps to the area of research and why you see this area as being of importance and interest. 

If applying online, you will need to upload your statement in the supporting documents section, or email the application form and statement to PGRAdmissions@mmu.ac.uk.

Closing date: 14 October 2024. Expected start date: January 2025 for Home students and April 2025 for International students. 

Please quote the reference: SciEng-2024-Platelet-Neuro

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