Postdoctoral Research Assistant UOD1673

We are recruiting for an exceptional individual to join us as a Postdoctoral Research Assistant within our Antigen Discovery Group, to support laboratory-based research in T cell antigen discovery. This is a fixed-term appointment for 3 years.

We are looking for a highly motivated Research Assistant with enthusiasm for T cell immunology and experience in sample preparation, analysis and interpretation of liquid chromatography mass spectrometry (LC-MS)-generated datasets. You will join the Antigen Discovery Group which aims to decipher the molecular architecture of the Human Leukocyte Antigen (HLA) processing and presentation machinery and study the effects of its function on T cell recognition in several disease models, including cancer. Processing samples of a variety of origins using standard lysis and immunoprecipitation, chromatography and mass spectrometry workflows, and data analysis will be an integral part of the position.

The position is central to the Antigen Discovery Laboratory and will support cutting-edge research ongoing in the wider institute. You will have the opportunity to formulate your own research projects and focus. You will have a background in Biology/Biochemistry (or a related discipline) with considerable bench science experience, and ideally with expertise of the analysis of peptides by liquid chromatography tandem mass spectrometry (LC-MS/MS). The post is located at the School of Life Sciences with access to a variety of facilities and its state-of-the-art mass spectrometry facilities. You will join a team of scientist that are passionate about HLA molecules and T cell antigen discovery for the development of next generation immunotherapies.

This postdoctoral research position requires you to hold a PhD. An appointment may be considered if you are shortly expected to be awarded a PhD. In this case the initial appointment would be made as a Research Assistant on the Training Grade 7 salary scale (£32,332-34,980).

Please note that applications made on a part-time basis for this role will be considered.

Your priorities will include:

• Manage your own schedule in the laboratory including sample preparation and cell culture.
• Lead data analysis using existing software packages and integration of further analysis tools into existing pipelines available in the group (training available)
• Oversee the generation of proteomic and immunopeptidome datasets from cells and primary mammalian tissue samples and apply scientific techniques and experimental protocols in the context of internal and external collaborations
• Keep up to date with latest developments in the field and contribute to project planning

Who we’re looking for:

• You have a Master’s degree or PhD with experience in bench laboratory science
• You have experience in working in a life sciences department, and are interested in contributing to translational research
• You have experience in cell culture and standard methods i.e. immunoprecipitation and nucleic acid extraction
• You have experience or like to gain experience with mass spectrometry-based peptide analysis
• You are interested in the principles of immune-recognition and T cells

For further information about this position please contact Dr Nicola Ternette at nternette001@dundee.ac.uk. To find out more about CSI please visit Cell Signalling and Immunology.

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