Location: | London |
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Salary: | £43,093 to £50,834 per annum |
Hours: | Full Time |
Contract Type: | Fixed-Term/Contract |
Placed On: | 2nd July 2024 |
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Closes: | 18th July 2024 |
Job Ref: | NAT01705 |
Location: The Francis Crick Institute
Job Summary
A Research Associate is available within the Chemistry Department at Imperial College London to work in the Walport laboratory (https://www.crick.ac.uk/research/labs/louise-walport) based at the Francis Crick Institute.
We are seeking a motivated chemical biologist to carry out novel research employing an mRNA-display-based peptide discovery platform, the RaPID system, to discover tools to understand the role of protein citrullination in early mammalian embryo development. Your work will involve developing new peptide tools to identify chemical modulators of the peptidyl arginine deiminases, optimising these tools for cellular delivery, and applying these tools in a range of structural, biochemical and cellular assays. The project will be multidisciplinary, involving synthetic and peptide chemistry, biophysical characterisation of peptide hits, structural biology and cell biology. We are therefore seeking someone with experience in a selection of these techniques and a willingness to learn others as dictated by the project. Experience with the development, optimisation and testing of peptide inhibitors or other chemical probes would be desirable.
The Walport lab is a highly interdisciplinary lab that uses a wide variety of techniques, spanning from synthetic and peptide chemistry to cell biology, to study proteins involved in the regulation of post-translational modifications. Our location in the Francis Crick Institute affords us access to a wealth of state-of-the-art technologies and expertise through the Scientific Technology Platforms alongside the stimulating environment provided by both the Crick and the Imperial College Chemistry Department.
Duties and responsibilities
Essential requirements
Further Information
The post is full-time and fixed term for 2 years. You will be based at the Francis Crick Institute.
Candidates who have not yet been officially awarded their PhD will initially be appointed as Research Assistant.
To apply, candidates should complete the online application form.
Should you require and further details on the role please contact Dr Louise Walport: l.walport@imperial.ac.uk
The Department of Chemistry proudly holds an Athena SWAN Gold Award and strives to provide a working environment where all our staff feel fully supported to flourish and excel. The Department of Chemistry is committed to promoting the wide range of Family Friendly policies and associated initiatives offered by the College.
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