Location: | London |
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Salary: | £46,593 to £54,630 per annum |
Hours: | Full Time |
Contract Type: | Fixed-Term/Contract |
Placed On: | 2nd July 2024 |
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Closes: | 2nd August 2024 |
Job Ref: | MED04681 |
Job Summary
The Ye lab invites applications from talented, highly motivated, and ambitious postdoctoral scientists for a Postdoctoral Research Associate (PDRA) position leading one or more projects investigating the relationship between build up and clearance of pathological protein aggregates associated with Parkinson’s disease and how removal of such aggregates may be enhanced as a therapeutic strategy for disease intervention. The project will investigate proteostasis systems in post-mortem donor samples and quantify the effect of aggregate load on IPSC-derived neurons. You will use a multidisciplinary approach (maintenance and manipulation of IPSC-neurons and established cell lines, super-resolution fluorescence imaging and various biochemical techniques) to unveil the mechansism of proteostasis mechanisms and the effect of therapeutic intervention strategies on pathological aggregates. This research will be driven in close collaboration with our industry partner Eisai.
This role is part of the Department of Brain Sciences at Imperial College London, located in. Postdocs in the Ye lab at Imperial enjoy excellent career development opportunities with:
Duties and responsibilities
As a Research Associate in the Ye lab, you will:
Essential requirements
You are a motivated and organised researcher, excited by the science we do.
With (or near completion of) a PhD in Cellular/Molecular Neuroscience with experience with IPSC cultures or in Neuropathology of Dementia (or related discipline), you will be strongly objective-driven, able to lead the project independently and put new knowledge into practice effectively.
Experimental expertise working with IPSC-differentiated neuronal culture, basic biochemistry and molecular biology is essential. Experience with advanced microscopy is a bonus.
Practical experience of quantitative image analysis, mass spectrometry or coding research projects is highly desirable in the lab.
Further Information
This position is offered fixed term on a full or part time basis for up to two-years.
Please contact Dr Yu Ye – yu.ye1@imperial.ac.uk for a discussion about the project and role.
Appointments are typically made to the first spine point of the scale.
Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range.
To apply, visit www.imperial.ac.uk/jobs and search by the job reference MED04681.
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