Postdoctoral Researcher in Circadian Neuroscience

We are seeking to appoint a talented, hard-working Postdoctoral Researcher in Circadian Neuroscience with a passion for neuroscience research. This project follows on from exciting findings by our group that the cryptochromes regulate voltage gated sodium channels in pain sensory nerves. Through better understanding of the mechanism, we aim to progress to development of drugs that can safely reduce pain without disrupting cellular clock function. You will utilise induced pluripotent stem cell (iPSC) derived nociceptors – in which you will perform electrophysiological studies, undertake genome engineering to generate required reporter lines - and perform mass-spectrometry proteomics to identify phosphorylation patterns and binding partners of the cryptochromes.

Essential selection criteria

• Have a PhD/DPhil in Biochemistry, in Molecular or Cellular Biology or Neuroscience
• Experience with electrophysiological assays – patch clamp recordings or sharp electrodes
• Experience with mammalian tissue culture
• Experience with molecular biology and biochemistry techniques – e.g. co-immunoprecipitation, affinity pull-downs
• Excellent interpersonal skills, communication and organisational skills
• Able to work independently and within a team

Desirable selection criteria

• Proven experience and success with human stem cell neuronal differentiation protocols
• Ability to differentiate iPSC into nociceptors
• Experience with genome engineering in human cells
• Experience with functional cellular assays e.g. calcium imaging, MEA
• Good publication track record and experience of presenting work at meetings

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