Research Fellow

Salary: Full time starting salary is normally in the range £36,130 to £45,413, with potential progression once in post to £48,149

Contract Type: Fixed Term contract up to March 2028

The post-holder will join a multidisciplinary team investigating structure/function relationships in the cellular activity of a hydroxylase-ligase pathway involved in gene expression control and nucleic acid repair. This exciting new pathway is unprecedented in biology and holds huge potential for discovery and scientific research career development. It builds on our discovery of a cytoplasmic lysyl hydroxylase that modifies a translation factor GTPase (Nature Chem Bio 2018; Genet Med 2023; Structure 2024; Cell Mol Life Sci 2021).

Here in this highly competitive BBSRC-funded project, you will unravel, for the first time, the role of this hydroxylated GTPase in nuclear ubiquitin biology. The findings will have significant importance for our understanding of fundamental cellular processes in both healthy and diseased cells. This project is hosted in the laboratory of Professor Mat Coleman, Head of Department of Cancer and Genomic Sciences, School of Medical Sciences, University of Birmingham UK (a world Top 100 University that ranks 59^th for Life Sciences and Medicine).

The postholder will:

• analyse and interpret research findings and results and contribute to manuscripts and grant applications. Present findings at national and international conferences and explore opportunities for career development.

• Apply cell biology, biochemistry, and omics approaches to identify and analyse novel enzyme/substrate complexes and new ubiquitylation targets involved in transcriptional elongation and nucleic acid repair. 

www.linkedin.com/in/mat-coleman-2190ab1b/

https://www.birmingham.ac.uk/staff/profiles/cancer-genomic/coleman-mathew

Person spec

• First degree in Biochemistry or a related discipline, a PhD (or one close to completion) or equivalent qualification and post-doctoral experience in nucleic acid repair, ubiquitin biology, and/or transcription.
• Demonstrable experience in DNA/RNA damage analyses, RNA biology, and/or analyses of gene expression control, including through advanced omics techniques.
• Demonstrable experience in deriving and analysing novel cell models, including through the application of Crispr, RNA interference, and/or targeted protein degradation.
• Demonstrable experience in ubiquitin ligase cell biology and biochemistry.
• Experience of proteomics and genomics. 
• High level analytical capability and familiarity with appropriate data collection/processing/analysis approaches and software.
• Ability to communicate complex information clearly.
• Evidence of contribution to grant applications and papers.
• Evidence of teaching experience and supervision of undergraduate, Masters, and PhD students
• Fluency in relevant models, techniques or methods and ability to contribute to developing new ones
• Ability to assess resource requirements and use resources effectively 
• Contribute to the planning and organising of the research programme and/or specific research project
• Co-ordinate own work with others to avoid conflict or duplication of effort
• Knowledge of the protected characteristics of the Equality Act 2010, and how to actively ensure in day-to-day activity in own area that those with protected characteristics are treated equally and fairly. 

Informal enquiries can be made to Mathew Coleman, email: m.coleman@bham.ac.uk

To download the full job description and details of this position and submit an electronic application online please click on the Apply button above.

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