Senior Research Associate-Bioinformatics

We are a world class research-intensive university. We deliver teaching and learning of the highest quality. We play a leading role in economic, social and cultural development of the North East of England. Attracting and retaining high-calibre people is fundamental to our continued success.

The Role
We are seeking a talented senior bioinformatician with a strong background in analysing next-generation sequencing data from cancer patients, to explore the genomic landscape of acute leukaemia and determine the clinical relevance of genetic and transcriptomic variation.

You will work as a member of the Leukaemia Research Cytogenomics Group (LRCG) in the Newcastle Translational & Clinical Research Institute at Newcastle University under the guidance of Professors Anthony Moorman and Christine Harrison and Dr Sarra Ryan. Initially your project will focus on the analysis of genomic data generated from samples taken from patients diagnosed with acute myeloid leukaemia (AML) and treated on the MyeChild01 clinical trial. The genomic dataset predominantly comprises whole transcriptomic (RNA) sequencing data but also includes data from whole genome sequencing, targeted DNA and RNA sequencing and optical genome mapping.

The project is part of the Cancer Research UK (CRUK) Experimental Medicine Award entitled "BIOINFORM: Biologically informed treatment decisions in acute leukaemia" award to Professor Moorman. The overall aim of the programme is to explore the genomic landscape of acute leukaemia and its association with clinical outcome. All the genomic datasets held by the LRCG are richly annotated with patient demographic, clinical, treatment and outcome; and correlating genetics with clinical features is a major part of our programme of research. You will work closely with internal and external collaborators who are experts in the biology and treatment of childhood and adult leukaemia to leverage our unique datasets to identify biomarkers and help improve the outcome of patients with acute leukaemia.

This is an excellent opportunity join a dynamic translational research group with a track record of improving patient diagnosis and management. You will have the opportunity to develop their research skills, learn new methods/techniques and progress to the next stage of their career. You will have a postgraduate degree in a relevant discipline and extensive experience in cancer bioinformatics, including developing analytical pipelines.

This appointment is a fixed-term post from 1st May 2025 until 30th April 2030.

To apply for the position, we'll need your CV and a cover letter outlining how you are suitable for the role using evidence to highlight how you meet the essential criteria in the knowledge, skills and experience as listed in the job description.

Informal enquiries are encouraged and can be made to Professor Anthony Moorman anthony.moorman@newcastle.ac.uk.

Further Information about the Faculty can be found at: https://www.ncl.ac.uk/fms/.

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