Research Associate in Cancer Genomics

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The Role
We are seeking an experienced research associate (RA) with a background in cancer genomics to implement a next-generation sequencing (NGS) assay for the detection of gene abnormalities in samples from patients with acute lymphoblastic leukaemia.

You will work as a member of the Leukaemia Research Cytogenomics Group (LRCG) in the Newcastle Translational & Clinical Research Institute at Newcastle University under the guidance of Professor Anthony Moorman and Dr Sarra Ryan. The aim of the project is to determine the prognostic impact of non-canonical genomic abnormalities in patients with acute lymphoblastic leukaemia treated on historic and contemporary treatment protocols. In collaboration with a commercial company, we will develop an NGS assay to screen a cohort of ~1,200 patients using existing samples. You will contribute to the design of the assay and development of the bioinformatic pipelines. In addition, they will lead on the processing of samples, transfer of samples/data to/from the commercial company and performing independent validation tests. You will have both bioinformatic and laboratory experience.

The project is part of the Cancer Research (CRUK) Experimental Medicine Award entitled "BIOINFORM: Biologically informed treatment decisions in acute leukaemia" award to Professor Moorman. The overall aim of the programme is to explore the genomic landscape of acute leukaemia and its association with clinical outcome. All the genomic datasets held by the LRCG are richly annotated with patient demographic, clinical, treatment and outcome; and correlating genetics with clinical features is a major part of our programme of research. You will work closely with internal and external collaborators who are experts in the biology and treatment of childhood and adult leukaemia to leverage our unique datasets to identify biomarkers and help improve the outcome of patients with acute leukaemia.

This is an excellent opportunity join a dynamic translational research group with a track record of improving patient diagnosis and management. The successful candidate will have the opportunity to develop their research skills, learn new methods/techniques and progress to the next stage of their career. You will have a PhD in a relevant discipline, experience in bioinformatics, knowledge of genomics and experience of performing molecular biology techniques.

This appointment is a fixed-term post from 1st May 2025 until 30th April 2030.

To apply for the position, we'll need your CV and a cover letter outlining how you are suitable for the role using evidence to highlight how you meet the essential criteria in the knowledge, skills and experience as listed in the job description.
Informal enquiries are encouraged and can be made to Professor Anthony Moorman anthony.moorman@newcastle.ac.uk.

Further Information about the Faculty can be found at: https://www.ncl.ac.uk/fms/.

Qualifications

• PhD in a relevant subject e.g. bioinformatics and/or molecular biology.

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