Research Associate (Genomics)

Location: Birmingham

Salary: Full time starting salary is normally in the range £32,546 to £35,116 with potential progression once in post to £39,355

Contract Type: Fixed Term contract up to December 2026

Join a groundbreaking research project funded by the Bill and Melinda Gates Foundation aimed at revolutionizing tuberculosis (TB) diagnostics. We're developing an innovative enzymatic lysis technique that addresses critical challenges in TB detection. Our approach tackles the complex mycobacterial cell wall using novel enzyme families, enabling rapid, low-cost diagnostic techniques. This research has the potential to dramatically improve TB testing accessibility, particularly in resource-limited settings, by creating a safer, more efficient method for extracting mycobacterial DNA for sequencing-based diagnostics and drug susceptibility testing. If you're passionate about transforming global health through innovative molecular biology and diagnostic technologies, this is your opportunity to make a meaningful impact in combating one of the world's most persistent infectious diseases.

The successful candidate will play a crucial role in developing an innovative TB diagnostic approach, collaborating across a multidisciplinary team to advance our novel enzymatic lysis technology. Key responsibilities include enzyme production and characterization, systematically testing enzyme cocktails against various Mycobacterial species to optimize DNA extraction efficiency. You will design and implement multiplex PCR protocols to generate amplicons, and utilize rapid nanopore sequencing techniques to validate and refine our end-to-end diagnostic test for drug resistance. The role demands meticulous laboratory work, involving molecular biology techniques, data analysis, and collaborative problem-solving to translate our research innovations into a practical diagnostic solution. Candidates will be expected to contribute to experimental design, conduct rigorous laboratory experiments, document results comprehensively, and participate in team discussions to iteratively improve our diagnostic methodology. 

Ideal candidates will possess a strong academic background in life sciences, with a minimum of an undergraduate degree in biochemistry, microbiology, biomedical science, or a closely related field. A master's degree is preferred. We are seeking candidates with demonstrable experience in molecular biology techniques, including DNA extraction, polymerase chain reaction (PCR), and sequencing methodologies. Specific technical skills we value include proficiency in laboratory techniques, experience with multiplex PCR, nanopore sequencing, and a demonstrated ability to work collaboratively in a research environment. Strong analytical skills, attention to detail, and the ability to document and communicate scientific findings clearly are essential. Candidates should be comfortable working in a fast-paced research setting, be adaptable to evolving research challenges, and show a genuine passion for innovative diagnostic technologies and global health solutions.

We are seeking a motivated molecular biologist to develop innovative diagnostic technologies for tuberculosis. The role involves creating novel enzymatic methods to extract mycobacterial DNA, designing multiplex PCR protocols, and using nanopore sequencing to create a rapid drug resistance diagnostic test. Working collaboratively, you'll conduct cutting-edge research to address critical challenges in TB detection. The ideal candidate will have a strong background in molecular biology techniques, a passion for global health, and the ability to translate scientific innovations into practical diagnostic solutions. 

Informal enquiries to Josh Quick: j.quick@bham.ac.uk 

To download the full job description and details of this position and submit an electronic application online please click on the Apply button above.

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