Senior Laboratory Research Scientist - Findlay Lab.

Location: The Francis Crick Institute, Midland Road, London

Short summary 

Studies of how genetic variants alter function have been historically hindered by limited means of genome editing. Now, CRISPR technologies present unprecedented opportunity to characterize human variants experimentally. Our lab drives progress in this area by developing high-throughput methods that enable us to test the effects of up to tens of thousands of variants per experiment.    

With generous funding from Cancer Research UK, we are collaboratively studying 100,000s of human variants across more than 15 cancer susceptibility genes. In the near term, research led by the successful candidate will include developing new assays to functionally characterize variants in many of these genes. The successful candidate will learn and apply cutting-edge technologies the lab has developed to genes that currently lack scalable functional assays.   

We are looking for an experienced scientist who has performed substantial lab-based research in genomics, genetics, molecular biology, stem cell biology, bioengineering, cancer biology, cell biology, or a related area. In-depth experience with current molecular biology methods, cell culture, and omics data analysis will prove highly beneficial. Familiarity with standard molecular biology methods is required, though specific experience with genome editing is unnecessary.    

Considerable flexibility and support will be given for skills development and for proposing future lines of study. The successful applicant will benefit highly from the thriving research environment of the lab, the broader Crick community, and the Institute’s excellent scientific technology platforms (STPs).   

To see the complete job description click here. 

To see more about team/Group Leader click here. 

Key Responsibilities

As an SLRS at the Crick, you will:  

• Manage day to day lab operations 
• Conduct research using cutting-edge technologies 
• Analyse large experimental data sets 
• Develop your own skills and propose future lines of study  

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council, Cancer Research UK, Wellcome, UCL, Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy. 

• If you are interested in applying for this role, please apply via our website.
• The closing date for applications is 23/03/2025
• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

Advert information