Postdoctoral Research Fellow

Full time: 35 hours per week

Fixed term: For 18 months

The Opportunity:

Precise electrical signalling at a millisecond time scale is critical for healthy functioning of the brain. Future advances in understanding functions and disorders of the brain will require new tools to resolve fast electrical signals in identified cells in freely moving mouse models. Recently developed fluorescent indicators enable electrical signals to be observed with microscopes. However, because current microscopes able to do this are bulky, they can only be used with mice that are restrained, which severely limits their usefulness.

To address this, we have been developing miniature microscopes that by incorporating novel imaging sensors are capable of ultra-high frame rate imaging of the electrical activity of populations of neurons in freely moving mice. The next phase of the project will be to 1) validate ultra-fast imaging through single cell electrophysiological recordings in vivo to provide important “ground truth” data and 2) test the technologies in freely behaving mice. If you are interested in combination of neuroscience and technology development and would like to know more, you can contact me at Ian.Duguid@ed.ac.uk or DM me on BlueSky @ianduguid.bsky.social. 

The salary for this post is £40,247 - £47,874 per annum.

Your skills and attributes for success: 

• A PhD in Neuroscience or related subject.
• Experience in quantitative analysis of rodent behaviour. 
• Experience in In vivo electrophysiology and/or 2-photon imaging. 
• Analysis of electrophysiology and/or imaging timeseries data.
• Rodent micro neurosurgery.

Demonstrable fluency in the Python (or related) programming language.

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