125th Anniversary Scholarship for Black British Researchers - Micro-engineered Integrated Non-invasive Diagnostic Technology of Traumatic Brain Injuries (MINDTBI)

Traumatic Brain Injury (TBI) is a leading cause of death worldwide. TBI is a major global health challenge, affecting 138 million people in 2022 and costing £912 billion in socioeconomic impact. With no regenerative capacity in brain tissue, early diagnosis is critical -life-saving decisions must be made within minutes to influence patient prognosis and treatment efficacy. However, early-stage detection remains a challenge, as many patients show no immediate symptoms, leading to delayed diagnosis and poor outcomes. Currently, no technology offers rapid, sensitive, point-of-care TBI detection to support early intervention, whether at the pitch side in contact sports or the roadside after accidents. The long-term effects of mild TBI and cumulative concussions further compound the issue, particularly for athletes. There is an urgent need for breakthrough diagnostics to enable timely, accurate triaging and treatment.

This project will develop a pioneering, portable micronano-engineered device using lithography-designed Surface-Enhanced Raman Spectroscopy in an optofluidic lab-on-a-chip. The system will enable low-cost, non-invasive early TBI diagnosis by detecting biomarkers from biofluids with high sensitivity. By providing real-time, reliable assessment, it will transform patient triaging, ensuring rapid and effective medical intervention.

With TBI costing the NHS £21 million annually, this project offers a high return on investment and significant potential as a point-of-care triage tool. Strategically, it will revolutionize neurodisease diagnostics, improving patient outcomes and saving lives. Conducted in collaboration with local hospitals, clinicians, and NIHR HRC-DDR, the research will ensure clinical relevance, NHS affordability, and direct patient benefits. The device will empower paramedics to assess injury severity in real time, enabling swift treatment decisions and targeted hospital triage. Early neuroprotective interventions will be initiated regardless of detailed diagnosis, with in-hospital confirmation.

Commercial impact will arise through IP exploitation, with clinical consultations optimizing the technology to meet critical medical needs. The project will drive high-impact publications, patents and industrial collaborations.

This multidisciplinary research integrates engineering, medicine, and biosciences. Led by experts from the University of Birmingham and QEHB, the supervisory team brings specialized expertise in nanomaterials, microfabrication, biology, and trauma research. State-of-the-art laboratories and technical support will ensure the project's success, fostering strong collaborations and translating scientific innovation into real-world clinical impact.

Beyond TBI, this technology holds immense potential for detecting other neurological conditions and monitoring drug delivery, ultimately improving healthcare and quality of life for millions worldwide. 

You can find more information via the above ‘Apply’ button.

Funding Details

Additional Funding Information

The University of Birmingham is proud to celebrate its remarkable 125-year journey and announce the launch of a groundbreaking scholarship initiative designed to empower and support Black British researchers in their pursuit of doctoral education.

These newly established 3.5-year scholarships aim to address underrepresentation and create opportunities for talented individuals from diverse backgrounds to excel in academia. You can find out more here: https://www.birmingham.ac.uk/study/postgraduate/research/funding/black-british-researchers-scholarship

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