Postdoctoral Project Research Scientist

Location: The Francis Crick Institute, Midland Road, London

Short summary

As a Postdoctoral Researcher at the Crick, you will: 

In this project, we aim to develop ZFPs which can upregulate CDKL2 mRNA expression and test if these can rescue molecular, cellular and behavioural defects in CDKL5 deficiency models. Postdoctoral researcher will generate and test zinc finger protein transactivators. They will then use CDKL5 knockout mouse models to determine if they can restore CDKL5-mediated functions at molecular and behavioural level. iPSC derived neurons of CDD models will also be used to test rescue of phosphorylation substrates.

Key Responsibilities 

As a Postdoctoral Researcher at the Crick, you will: 

In this project, we aim to develop ZFPs which can upregulate CDKL2 mRNA expression and test if these can rescue molecular, cellular and behavioural defects in CDKL5 deficiency models. Postdoctoral researcher will generate and test zinc finger protein transactivators. They will then use CDKL5 knockout mouse models to determine if they can restore CDKL5-mediated functions at molecular and behavioural level. iPSC derived neurons of CDD models will also be used to test rescue of phosphorylation substrates. 

You will bring…  

Essential

• PhD in biology, biochemistry, neuroscience or a related discipline or in the final stages of PhD submission
• Good knowledge of molecular biology skills
• Track record of writing papers as evidenced by publications or submitted manuscripts in referred journals
• Evidence of data presentation at scientific meetings

Desirable but not essential

• Experience in research with iPSC derived neurons
• Experience in RNA sequencing
• Experience in mass spectrometry
• Experience in neonatal brain injections or in utero electroporation
• Experience in mouse behavioural analysis

To see the complete Job Description click here for more info.  

To see more about the lab, click here.   

About us…  

The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. 

The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We’ve removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.  

• If you are interested in applying for this role, please apply via our website.
• The closing date for applications is 16/02/2025
• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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