Principal Laboratory Research Scientist

Location: The Francis Crick Institute, Midland Road, London

Short summary

We are seeking an enthusiastic and ambitious Principal Laboratory Research Scientist to join the Tissue Regeneration and Clonal Evolution (TRCE) laboratory. We are a multi-disciplinary research group with a mission to understand the factors underlying an organ’s regenerative capacity in order to design novel therapeutics to augment biological function. 

We use the liver as a model organ since it has extraordinary regenerative abilities. We have already identified several interesting genes in metabolic pathways which we hypothesise are important in allowing liver cells to survive better in pathological conditions (Ng. et al, Nature, 2021). We aim to elucidate the functional consequences of mutations in these genes and unravel how these molecular perturbations influence hepatocyte clonal biology and the mechanisms of tissue regeneration. We model these recurrent human somatic driver mutations using patient derived induced pluripotent stem cells (Rouhani et al. Nature Genetics, 2022), organoids and bio-engineered tissues. We are also developing and applying new technologies in single molecule spatial genomics and in vivo gene editing. 

If you are a senior scientist, this may be an excellent opportunity for you to join the lab. You will be heavily involved in the start-up of a major laboratory and will provide senior level support in broad scientific management for the research group. Alongside providing technical assistance to other lab members, there will be opportunities and strong encouragement for you to lead independent projects in areas such in vivo gene editing and liver epigenetics. 

Key Responsibilities

As a Principal Laboratory Research Scientist at the Crick, you will be: 

• Independently devising and leading projects within the TRCE research program 
• Establishing new methodologies in the lab 
• Maintaining laboratory organisation and supplies 
• Supporting the Group Leader in day-to-day operations 
• Deputising for when the Group Leader is unavailable 
• Training and supporting lab members in standard operating procedures 
• Facilitating collaborations within and outside the Crick 

About us

The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.  

The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We’ve removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.   

• If you are interested in applying for this role, please apply via our website.
• The advert is open ended
• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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