Principal Laboratory Research Scientist - Human Biology Facility

Location: The Francis Crick Institute, Midland Road, London

Short summary 

About the role…

The Human Models Core (HMC) is an integral part of the Human Biology Facility. Operated by a team of scientific and technical experts, the HMC offers a portfolio of services and support to researchers. Working closely with the Human Biology Governance Team and research groups at the Crick, the HMC is aimed to facilitate a broad spectrum of human models research. The core operates in a number of specialized areas, including viral vectors, pluripotent stem cells, genome editing and cell engineering, primary cells and organoids.

We are seeking a highly motivated, proactive stem cell expert with deep knowledge and understanding in reprogramming pluripotent stem cells (PSC), differentiation and gene editing. In addition, the candidate should have an understanding of primary human models and their application. The successful candidate will take the lead on reprogramming projects, support and advise of differentiation projects, gene editing projects and the generation of human 2D and 3D models.

You will bring…

• Identifying, managing and delivering robust scientific support to Crick Researchers
• Project delivery of reprogramming portfolio
• Support gene editing projects in PSC
• Reprogramming somatic cells to pluripotent stem cells.
• Register reprogrammed cell lines
• Establishing new methodologies in the lab
• Developing proof-of-concept for new research directions
• Horizon scanning and developing specific scientific projects and platforms within the facility in a collaborative setting
• Supporting research groups, Head of Lab ops in grant writing and publications
• Provision of tissue culture, quality control and technical support to research groups within the Francis Crick Institute
• Teaching and training scientists in the best practice skill sets necessary to grow, characterise, differentiate and bank human pluripotent stem cells

About you…

• Degree in a biological subject with substantial post-graduate experience in pluripotent stem cell research
• PHD or equivalent experience
• Extensive wet lab experience in pluripotent cell culture
• Experience in reprogramming cells to pluripotency
• Experience in PSC model development
• Proven track record in scientific publication
• Demonstrable experience with best practice, quality control assessment and related assays
• Highly self-motivated with a pro-active approach
• To see the complete job description, click here for more info!  

About us…

The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.

The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We’ve removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.

• Closing date 3^rd Feb 2025 

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