Senior Laboratory Research Scientist

The successful candidate will join the MANIFEST programme within the Cancer Dynamics research group and will work closely with the Experimental Histopathology Science Technology Platform (STP), providing advice, training, and expertise in a range of techniques to analyse human cancer specimens for translational research within the MANIFEST platform.  Their time will be spent in the lab, with a primary responsibility for optimising and performing automated Immunohistochemistry (IHC), multiplex Immunofluorescence (mIF), and RNAScope on tissue sections derived from formalin-fixed paraffin-embedded (FFPE) human cancer tissue blocks.

The post holder will also be involved in the development of new technologies relating to spatial transcriptomics and integrated proteomics with the opportunity to collaborate with leading technical platforms (Leica Bond RX, Akoya, 10X Genomics), as well as access to expertise across the broader consortium. Whilst the primary responsibility of the role is to support spatial multiomic  pipelines within the MANIFEST Histology platform, additional responsibilities will include slide scanning and image pre-processing plus general lab organisation/administration.

Key Responsibilities

• Exemplifying and maintaining standards for the Histology platform
• Conducting experimental work autonomously and by own initiative as agreed with the Spatial Lead and Programme Lead
• Operating as a technical specialist in IHC/mIF and ISH (RNAScope) staining and spatial transcriptomics staining projects
• Interacting with and consulting collaboratively with researchers
• Actively supporting and training team members to develop their skills and promote collective success
• Use of knowledge to build on existing methodologies and innovate through Identification, assessment and development of new technologies, to expand the capabilities of the platform under guidance of Spatial lead
• Supporting and contributing to existing projects through effectively and efficiently performing established techniques
• Contribution to the day-to-day operations to ensure the laboratory runs as efficiently as possible

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council, Cancer Research UK, Wellcome, UCL, Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

• If you are interested in applying for this role, please apply via our website.
• The closing date for applications is 21/01/2025
• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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