Postdoctoral Fellow – [C Swanton] Cancer Evolution and Genome Instability Laboratory

The Cancer Evolution and Genome Instability lab are studying how cancers evolve in the body to spread and become resistant to therapy and finding new ways to treat them more effectively.

Lung cancer remains one of the most pressing public health concerns worldwide, demanding innovative research to address its complexities and challenges. To this end, our research presents two distinct yet intertwined project directions for a postdoc candidate. We are seeking applications from candidates with a broad range of competencies.

The first research direction investigates the role of non-mutagenic carcinogens in lung cancer initiation. Recent studies have brought to light the fact that most carcinogens do not solely rely on DNA mutations to drive cancer development.

The second research direction focuses on the impact of clonal hematopoiesis of indeterminate potential (CHIP)-the age-related acquisition of somatic mutations in hematopoietic stem cells—on lung cancer progression.

Key Responsibilities

The postholder will be responsible for:

• Working within the multi-disciplinary team of clinicians, bioinformaticians and bench scientists in the Swanton lab, and collaborating with groups at the Francis Crick Institute and beyond, including academic and industry partners
• Driving the project forward using relevant experimental and/or computational approaches
• Keeping up to date with the relevant literature in the field of cancer biology
• Attending and reporting research results at regular group meetings
• Contributing to the dissemination of scientific results by means of writing papers for publication and presenting orally and in poster form at national and international meetings

Postdoctoral Fellows will lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and may guide PhD students in their research. The ability to work in a team is essential.

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council, Cancer Research UK, Wellcome, UCL, Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

• If you are interested in applying for this role, please click the 'Apply' button.
• The closing date for applications is 19/01/2025
• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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