Research Assistant in Anti-Inflammatory Strategies

About the role

This is an exciting opportunity to work on cardio-immunology within King’s BHF Centre of Excellence. Myocardial infarction is the commonest cause of heart failure and there is compelling evidence implicating excessive inflammation as a key contributor. Cardiac-resident leucocyte subsets are important mediators of the inflammatory response to cardiac injury, but it is not clear how signalling in these cells is regulated. 

The project aims to delineate signalling in leucocytes after myocardial infarction using in vivo models and multi-platform ‘omics’ approaches. These studies will provide invaluable knowledge on the regulation of inflammation after MI. We aim to identify and target novel signalling pathways and genomic and transcriptional regulators of inflammation that we can translate to the bedside to alleviate progression to heart failure. 

We are seeking a motivated and enthusiastic candidate to join our pre-clinical and translational research. The successful applicant will be expected to develop and undertake research of high quality consistent with the aims of the project. They will contribute to all facets of the lab, including managing specific work packages and working as part of a multi-disciplinary team. The post will be originally offered for 2 years with the possibility of extension.

This is a full-time post (35 hours per week), and you will be offered a fixed term contract until 5th January 2027.

About you

To be successful in this role, we are looking for candidates to have the following skills and experience:

Essential criteria 

• Have proven expertise in working with primary cells; be able to perform routine molecular biology protocols, such as DNA isolation, PCR, cell culture and treatment, cell fractionation, flow cytometry, ELISA, and functional assays.
• Possess scientific integrity and understanding of the importance of study design, power calculations and statistical analysis, as well as understanding the scientific foundation of experiments.
• Commitment to continuing personal and professional development.
• Good written presentation skills, communication skills (written & verbal), and IT skills.
• Ability to work independently and integrate with colleagues, work as part of a team, and undertake a share of group tasks. 
• Able to carry out known/learnt techniques unsupervised and be flexible/able to change in current professional context.
• Proven ability to manage own research and administrative activities efficiently, prioritise, meet targets and deadlines, and keep clear and well-organised laboratory notes and records.

Desirable criteria

• Experience of wet lab workflows for bulk and single cell RNA sequencing.  
• Hold a Home Office personal licence.
• Experience of genomics and bioinformatic workflows. 

Downloading a copy of our Job Description

Full details of the role and the skills, knowledge and experience required can be found in the Job Description document, provided at the bottom of the next page after you click the “Apply” button, above. This document will provide information of what criteria will be assessed at each stage of the recruitment process.

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