Senior Laboratory Research Scientist

Location: The Francis Crick Institute, London

Short summary 

Do you have a keen interest in biological mass spectrometry and applying state-of-the-art proteomic technologies? 

We have an opportunity for a talented, experienced, and motivated Senior Laboratory Research Scientist in the Proteomics Scientific Technology Platform at the Francis Crick Institute. The post holder will help us provide a world class platform to contribute towards key research in collaboration with the wider Crick scientific community.  This is a lab-based position, responsible for driving forward qualitative and quantitative proteomic and clinical proteomic projects, from experimental design through sample preparation to data analysis. 

The Proteomics STP houses a broad range of mass spectrometers including a Thermo Scientific Orbitrap Eclipse Tribrid with FAIMS and ETD, Exploris 480, Q Exactive UHMR, Bruker timsTOF Ultra and Pro2, Waters Select Cyclic and SYNAPT G2Si HDMS.  The role will involve setting up new experiments as collaborative projects arise using the available mass spectrometry technologies to both qualitatively and quantitatively measure proteins.

Key Responsibilities

These include but are not limited to: 

• Planning of experiments, decision making about which pipeline to take, and independently executing experiments for projects.
• Performing both standard and bespoke proteomics experiments starting with sample preparation from a variety of biological sources using common biochemical methodologies for cell lysis, SDS-PAGE, in-gel, in-solution, TCA and acetone precipitation digest protocols, TMT labelling, high pH chromatographic fractionation and label free quantification.
• LC-MS/MS nanoUHPLC data acquisition, evaluation, and processing of raw data.
• Communication of results in collaboration. 

Other typical activities may include: 

• Collaborating with other lab members on/Assisting other lab members with/ research projects.
• Providing experimental or technical support to other lab members.
• Providing technical expertise/ input for the development, refinement and troubleshooting of novel methodologies.
• Participating in academic activities, including group meetings and journal clubs, seminars 

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council, Cancer Research UK, Wellcome, UCL, Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy. 

• If you are interested in applying for this role, please apply via our website.
• The closing date for applications is 15/12/2024
• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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