Research Assistant

About us

The mission of the UCL GOS Institute of Child Health is to maximise and advocate for the holistic health of all children, young people and the adults they will become, through world-class research, education and public engagement. The UCL GOS ICH, together with its clinical partner Great Ormond Street Hospital for Children, forms the largest concentration of children’s health research outside North America. The 2024-29 GOS ICH strategy focuses on its five scientific programmes. GOS ICH’s activities include active engagement with children and families, to ensure that our work is relevant and appropriate to their needs. The Institute offers world-class education and training across a wide range of teaching and life learning programmes which address the needs of students and professional groups who are interested in and undertaking work relevant to child health. GOS ICH holds an Athena SWAN Charter Gold Award.

About the role

The project aims to compare the efficacy of 2 adeno-associated viral (AAV) vectors in a rare disease affecting the liver-based urea cycle, argininosuccinate lyase (ASL) deficiency. ASL deficieny is the second most common urea cycle disorder. This causes acute hyperammonaemia and a chronic systemic disease, affecting especially the liver with fibrosis/cirrhosis. The successful applicant will in charge of the mouse colony, assess efficacy of the neonatal AAV gene therapy, and perform liver immunostaining and analysis of biomarkers at the end of the project. Please see the job description for more details.

About you

We expect the successful applicant to have a MSc in Biomedical Sciences and a background in gene therapy, inherited metabolic disease and in vivo mouse work. The applicant needs to demonstrate strong motivation, ability to commit to deadlines, ability to present his research with presentation at conferences and publications in high-ranking jo urnals. Please see the job description for more details.

What we offer:

Visit https://www.ucl.ac.uk/work-at-ucl/reward-and-benefits to find out more.

Our commitment to Equality, Diversity and Inclusion

As London’s Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world’s talent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong. We therefore particularly encourage applications from candidates who are likely to be underrepresented in UCL’s workforce. These include people from Black, Asian and ethnic minority backgrounds; disabled people; LGBTQI+ people; and for our Grade 9 and 10 roles, women. You can read more about our commitment to Equality, Diversity and Inclusion here : https://www.ucl.ac.uk/equality-diversity-inclusion/ If you have any queries regarding the application process, p lease contact Madhur Sharma on ich.hr@ucl.ac.uk.

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