Senior Postdoctoral Researcher - UOD1783

We are recruiting highly motivated and experienced senior postdoctoral researchers to participate in a new academic-industrial global initiative supported by the Michael J Fox Foundation for Parkinson’s Research. The project aims to: (1) Explore and validate new approaches to target LRRK2; (2) Perform systematic mechanistic, structural and safety analyses to benchmark new LRRK2 modifiers that emerge from this effort and (3) identify clinically relevant biomarkers for LRRK2-driven Parkinson’s disease that will facilitate the selection of patients who respond to LRRK2 inhibitor therapy. We aim to galvanise research and accelerate the development of Parkinson’s disease therapeutics. These positions enable further training in state-of-the-art methods through the course of the project, and involve wider collabora tion with Protein Phosphorylation and Ubiquitylation Unit members, other academic Institutions worldwide and industrial partners working in this area.

The appointed post holders will be based within the laboratories of Dario Alessi, Esther Sammler and Paul Davies within the University of Dundee’s MRC Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU, http://www.ppu.mrc.ac.uk/).

The successful candidate will be expected to independently design, develop and implement a range of strategies and approaches required across different projects and to supervise and guide other research team members in the delivery of their project. In addition, the successful candidate will be responsible for the day-to-day project leadership with minimal input from the Principal Investigators, and data and resource management.

Your priorities will include:

• To lead a research project in the relevant discipline area using the appropriate methods and/or techniques.
• To take responsibility for project development and implementation, including experimental design and identification and development of a broad range of techniques necessary to achieve the research objectives.
• To independently design, develop and implement a range of strategies and approaches required across different projects.
• Be responsible for the day-to-day project leadership with minimal input from the Principal Investigators, and data and resource management.
• To provide supervision, guidance and support to other staff and students within the research team.

Who we’re looking for:

• Applicants must have a PhD in a relevant discipline with strong academic track record and at least one first authored publication either submitted to a preprint server or published in an internationally recognised peer-reviewed journal.
• Significant relevant experience in academic or industrial environment along with demonstrated track record of project leadership roles.
• Strong knowledge and interest in understanding pathways that are linked to neurodegeneration and Parkinson’s disease and an appreciation of how research in this area can be exploited to accelerate drug discovery.
• Demonstrated experience in the design, development and implementation of a range of strategies and approaches required for the successful delivery of a research project.
• Experience in supervision of junior members of a research team.
• Significant hands-on expertise in one or more of the following: biochemistry, mass spectrometry, cell biology, molecular biology, structural biology, signal transduction, data analysis and bioinformatic analysis.
• Hands-on experience in experimental techniques and data analysis that are relevant to the role.
• Experience in independent research projects including interdisciplinary work.

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