Postdoctoral Training Fellow - Post-translational Modifications and Cell Proliferation

Salary: £41,607 - £47,370 dependent on relevant Postdoctoral experience. Future progression is based on annual performance review. If the candidate has completed their viva but has not yet been awarded their PhD, the starting salary will be £35,844, pre-PhD level. Progression to the full PDTF scale will commence once confirmation of PhD award is received. Award must be provided within 6 months of start date.

This role is eligible for ICR Sponsorship. Support will be provided for costs associated with Visa application. If you are considering relocating to the UK, further information can be found here. 

Duration of Contract: Fixed term for 3 years

Hours per week: 35 hours per week (Full Time)

Closing Date: 15 December 2024, with interviews in January 2025

Job Details

Under the leadership of Dr. Jörg Mansfeld, we are seeking a highly motivated and ambitious candidate for a Postdoctoral Training Fellow position, with experience in cell cycle research, ubiquitin, or redox biology. This position will build on our recent work on CDK2 and p21 oxidation, as well as cell cycle-dependent redox proteomics, to investigate the interplay between protein oxidation, ubiquitinylation, and phosphorylation in both non-transformed and cancer cells. We collaborate with several groups at the ICR to validate our findings in animal models and patient samples. The successful candidate will have the intellectual freedom to develop the project, with support from the Group Leader, while working as part of a collaborative and multidisciplinary team.

More information can be found in the Job Description Pack (see download link to the right).

For general information on Post Doc's at The ICR can be found here.

Key Requirements

The successful candidate must have previous experience in cell cycle, ubiquitin, or redox research. A strong cell biology or biochemistry background with an emphasis on the regulation of protein-protein interactions and mechanistic studies in vitro or in cells is highly desirable. Knowledge in DNA replication and/or DNA damage repair is desirable.

The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up  to 7 years as PDTF at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 10 years.

Post-translational Modifications and Proliferation Group

The Post-translational Modifications and Proliferation Group investigates the intricate regulation of cell cycle control through post-translational modifications (PTMs). We focus on the interplay of thiol oxidation with phosphorylation and ubiquitylation in the context of cell cycle regulation. We employ cutting-edge mass spectrometry to identify PTMs, advanced gene-editing, and single-cell imaging to investigate the physiological impact of PTMs. Experimental models include 2D and 3D cell culture with a focus on non-transformed  cell models and breast cancer. More information about our work can be found at www.mansfeldlab.com.

Our team is embedded within the Cancer Biology Division at the ICR’s Chester Beatty Laboratories in Chelsea, London. We have a highly supportive and interactive research environment, and state of the art facilities for cell biology, molecular biology, next-generation sequencing and structural biology. We also closely interact with other divisions at the ICR, including Breast Cancer Research, Radiotherapy and Imaging, and Structural Biology. The great variety of disciplines at the ICR will ensure that the successful candidate will be exposed to fantastic research and seminars from all types of backgrounds. 

Download the job pack for more detailed information regarding this role. For an informal discussion regarding the role, please contact Dr. Jörg Mansfeld via email: jorg.mansfeld@icr.ac.uk.

To apply, please click on the ‘Apply’ button above.

About The Institute of Cancer Research

Why work for us?

As a member of staff, you'll have exclusive access to a range of staff benefits.

The ICR is committed to supporting overseas applicants applying for roles, please click here to find out further information.

The Institute of Cancer Research, London, is one of the world's most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. Further information about working at the ICR can be found here.

At the Institute of Cancer Research, we champion diversity as we believe it fuels innovation and drives impactful research. We welcome applicants from all walks of life, valuing diverse perspectives that enrich our work.

Don't let a checklist of qualifications hold you back – if you're passionate about the role, we want to hear from you. Your unique experiences and backgrounds contribute to the richness of our team. We are committed to being an equal opportunity for all, regardless of ethnicity, gender, age, sexual orientation, disability, or any other dimension of diversity. Join us in creating an inclusive environment where everyone's voice is heard and valued.