PhD Studentship: Signalling pathways that mediate the dual origins of the dorsal aorta

Primary Supervisor - Professor Andrea Münsterberg 

Embryo development is a fascinating process generating a highly organised body plan with many features that are conserved across different vertebrate species. This includes the metameric organization of the vertebrae and the associated skeletal muscles, nerves and blood vessels, produced by somites residing on each side of the neural tube. In previous work, we have determined molecular profiles of somites and adjacent tissues along the anterior-posterior axis of developing chick embryos. This identified accessible chromatin, differentially expressed genes and cis-regulatory elements (CRE) active in specific cell lineages. This project will investigate the functions of candidate genes arising from these data sets. Specifically, the student will investigate signalling interactions between somites and the lateral plate mesoderm (LPM), focussing on Wnt, FGF and BMP pathways. Signalling cross-talk between somite and LPM is important for the formation of the dorsal aorta, a bilateral primary vessel, which will fuse and later form major arteries in the head, neck and trunk. Furthermore, the dosal aorta is the source of hematopoietic stem cells within the organism, thus, its formation is of fundamental importance. Insights gained have potential relevance for regenerative medicine and tissue engineering. The project will use in vivo approaches for gene function analysis, genome editing and microscopy including live imaging and thus provide training in experimental embryology. An experienced team of supervisors will support the successful student candidate, who should be motivated and curious. Scientific collaborations, conference attendance and outreach activities will provide further training - in addition to opportunities offered by the DTP, UEA and the NRP. 

The Norwich Research Park Biosciences Doctoral Training Programme (NRPDTP) is offering fully funded studentships for October 2025 entry. The programme offers postgraduates the opportunity to undertake a 4-year PhD research project whilst enhancing professional development and research skills through a comprehensive training programme. You will join a vibrant community of world-leading researchers. All NRPDTP CASE students undertake a three to 18-month placement with the non-academic partner during their study. The placement offers experience designed to enhance professional development. Full support and advice will be provided by our Professional Internship team. Students with, or expecting to attain, at least an upper second-class honours degree, or equivalent, are invited to apply. 

This project has been shortlisted for funding by the NRPDTP. Shortlisted applicants will be interviewed on 28, 29 or 30 January 2025.  

Visit our website for further information on eligibility and how to apply: https://biodtp.norwichresearchpark.ac.uk/ 

Our partners value diverse and inclusive work environments that are positive and supportive. Students are selected for admission without regard to gender, marital or civil partnership status, disability, race, nationality, ethnic origin, religion or belief, sexual orientation, age or social background. 

Additional Funding Information

This project is awarded with a 4-year Norwich Research Park Biosciences Doctoral Training Partnership PhD DTP studentship. The studentship includes payment of tuition fees (directly to the University), a stipend to cover living expenses (2024/5 stipend rate: £19,237), and a Research Training Support Grant of £5,000pa for each year of the studentship. 

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