Back to search results

PhD Studentship: Is glutamine the answer to reversing blood stem cell ageing

University of East Anglia - Norwich Medicine School

Qualification Type: PhD
Location: Norwich
Funding for: UK Students, EU Students, International Students
Funding amount: £19,237 stipend for 2024/5
Hours: Full Time
Placed On: 24th October 2024
Closes: 25th November 2024
Reference: RUSHWORTH_U25DTP1

Primary Supervisor - Professor Stuart Rushworth 

As our ageing population grows it is becoming increasingly important to better understand the changes that occur during physiological ageing. Ageing drives intrinsic metabolic changes that alter normal physiology and result in tissue dysfunction and the development of numerous age-related diseases. This project will aim to better understand the age-related metabolic changes that occur in blood stem cells with a focus on glutamine metabolism and the impact this has on blood production. Whilst our previous work has demonstrated that the environment in which blood stem cells reside contributes to the impaired response to infection other preliminary has shown that blood stem cells also acquire intrinsic changes that may alter their metabolic function.  Therefore, this project aims to study the intrinsic metabolic changes of blood stem cells and how this impacts metabolic output.  The PhD student will be trained in vivo techniques including animal handling, isolation of primary cells and techniques to assess metabolic and functional characteristics of cells including FACS analysis, liquid chromatography/mass spectrometry to track metabolites, qPCR to analyse nucleic acids and western blot, ELISA and metabolic assays. This will give them a number of valuable transferrable skills which will help their scientific career progression. The project will be carried out at the Rushworth Lab based at Norwich Medical School, UEA, which combines research laboratories with medical training facilities. 

The Norwich Research Park Biosciences Doctoral Training Programme (NRPDTP) is offering fully funded studentships for October 2025 entry. The programme offers postgraduates the opportunity to undertake a 4-year PhD research project whilst enhancing professional development and research skills through a comprehensive training programme. You will join a vibrant community of world-leading researchers. All NRPDTP CASE students undertake a three to 18-month placement with the non-academic partner during their study. The placement offers experience designed to enhance professional development. Full support and advice will be provided by our Professional Internship team. Students with, or expecting to attain, at least an upper second-class honours degree, or equivalent, are invited to apply. 

This project has been shortlisted for funding by the NRPDTP. Shortlisted applicants will be interviewed on 28, 29 or 30 January 2025.  

Visit our website for further information on eligibility and how to apply: https://biodtp.norwichresearchpark.ac.uk/ 

Our partners value diverse and inclusive work environments that are positive and supportive. Students are selected for admission without regard to gender, marital or civil partnership status, disability, race, nationality, ethnic origin, religion or belief, sexual orientation, age or social background. 

Additional Funding Information

This project is awarded with a 4-year Norwich Research Park Biosciences Doctoral Training Partnership PhD DTP studentship. The studentship includes payment of tuition fees (directly to the University), a stipend to cover living expenses (2024/5 stipend rate: £19,237), and a Research Training Support Grant of £5,000pa for each year of the studentship. 

We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information

Type / Role:

Subject Area(s):

Location(s):

PhD tools
 

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Ok Ok

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Manage your job alerts Manage your job alerts

Account Verification Missing

In order to create multiple job alerts, you must first verify your email address to complete your account creation

Request verification email Request verification email

jobs.ac.uk Account Required

In order to create multiple alerts, you must create a jobs.ac.uk jobseeker account

Create Account Create Account

Alert Creation Failed

Unfortunately, your account is currently blocked. Please login to unblock your account.

Email Address Blocked

We received a delivery failure message when attempting to send you an email and therefore your email address has been blocked. You will not receive job alerts until your email address is unblocked. To do so, please choose from one of the two options below.

Max Alerts Reached

A maximum of 5 Job Alerts can be created against your account. Please remove an existing alert in order to create this new Job Alert

Manage your job alerts Manage your job alerts

Creation Failed

Unfortunately, your alert was not created at this time. Please try again.

Ok Ok

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

 
 
 
More PhDs from University of East Anglia

Show all PhDs for this organisation …

More PhDs like this
Join in and follow us

Browser Upgrade Recommended

jobs.ac.uk has been optimised for the latest browsers.

For the best user experience, we recommend viewing jobs.ac.uk on one of the following:

Google Chrome Firefox Microsoft Edge