Senior Laboratory Research Scientist

Location: The Francis Crick Institute, Midland Road, London

Short summary

We are looking for an enthusiastic and proactive scientist to work with us within our EPSRC-funded Prosperity Partnership collaboration between the Francis Crick Institute and GSK. In this collaboration we are employing covalent fragment screening to simultaneously identify potential new drug targets and small molecules tools. See: https://www.crick.ac.uk/news/2021-04-02_francis-crick-institute-and-gsk-to-pioneer-reactive-fragment-screening-in-drug-discovery

We have already established a high-throughput chemoproteomic platform that enables covalent fragment screening in cells and have identified many novel protein-small molecule interactions which we now want to explore and develop into high quality molecular probes. We are now looking for a Senior Laboratory Research Scientist to join our multi-disciplinary team and work with us on the biochemical and structural characterisation of these newly identified protein-compound interactions to support the rapid generation of tool molecules for disease-relevant protein targets.

The role will focus on work within the EPSRC- funded Crick-GSK Prosperity Partnership collaboration.

Key Responsibilities

• Production of recombinant proteins and subsequent biochemical and structural characterisation of protein-compound complexes
• Establishing biochemical and biophysical assays to study the effect of compound engagement on enzymatic activities or protein-protein interactions
• Working closely with chemists to explore structure-activity relationships
• Collaborating with other lab members on research projects.
• Participating and presenting in group meetings, seminars, and scientific meetings.
• Writing up findings for publication. 

Experience and Competencies

The post holder should embody and demonstrate our core Crick values:

Bold; Open; Collegial 

Essential

• PhD or M.Sc. in biochemistry or related discipline,
• Broad experience in recombinant protein production
• Experience in the use of biophysical techniques to study protein-protein and protein-ligand interactions
• Excellent technical and problem-solving skills
• Excellent organisational and time-management skills
• Self-motivated with the ability to work both independently and as part of a team
• Strong communication skills to work with diverse scientists 

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council, Cancer Research UK, Wellcome, UCL, Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy. 

• If you are interested in applying for this role, please apply via our website.
• The closing date for applications is 10/11/2024
• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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