Research Fellow in Structural Biology

Location: Leeds - Main Campus

Are you an ambitious researcher looking for your next challenge? Do you have an established background in Structural Biology, particularly Cryo-Electron Microscopy (cryo-EM), NMR or HDX-MS? Do you want to further your career in one of the UKs leading research intensive Universities?

Based in the laboratories of Professor Alex Breeze and Dr Stephen Muench at the Astbury Centre for Structural Molecular Biology, you will work on an exciting project deciphering the chaperone interaction cycle of fibroblast growth factor receptors (FGFRs).

The project is funded for 9 months by the Biotechnology and Biological Sciences Research Council (BBSRC) and will involve solving high-resolution structures of complexes of FGFR intracellular domain with HSP90 and Cdc37 chaperone components using cryo-EM, as well as investigating dynamics and interaction epitopes using NMR spectroscopy and hydrogen-deuterium exchange (HDX-MS). Exceptional facilities and training are available in Leeds to support the project, including two Titan Krios electron microscopes equipped with the latest detectors as well as state-of-the-art cryoprobe-equipped NMR spectrometers including Bruker Avance III HD Aeon 950 MHz and Waters Synapt HDMS IM-MS, HDX and FPOP mass spectrometers.

You should have a PhD (or close to completion) in structural biology or a closely allied discipline, with experience in cryo-EM and potentially also NMR spectroscopy and/or structural MS, as well as protein expression, purification and labelling for the study of large proteins.

Please note that this post may be suitable for sponsorship under the Skilled Worker visa route but first-time applicants might need to qualify for salary concessions. For more information, please visit: Skilled Worker visa: Overview - GOV.UK (www.gov.uk)

For research and academic posts, we will consider eligibility under the Global Talent visa. For more information, please visit: www.gov.uk/global-talent

What we offer in return

• 26 days holiday plus approx.16 Bank Holidays/days that the University is closed by custom (including Christmas) – That’s 42 days a year!
• Generous pension scheme plus life assurance– the University contributes 14.5% of salary
• Health and Wellbeing: Discounted staff membership options at The Edge, our state-of-the-art Campus gym, with a pool, sauna, climbing wall, cycle circuit, and sports halls.
• Personal Development: Access to courses run by our Organisational Development & Professional Learning team.
• Access to on-site childcare, shopping discounts and travel schemes are also available.

And much more!

To explore the post further or for any queries you may have, please contact:

Professor Alex Breeze, Professor of Biomolecular NMR

Tel: +44 (0)113 343 0087

Email: a.l.breeze@leeds.ac.uk

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