Senior Laboratory Research Scientist

Location: The Francis Crick Institute, Midland Road, London

Short summary

The Research Group

The laboratory of Tumour-Immune Communication has been established in early 2024. We study bidirectional interactions between cancer cells and the host immune system using synthetic and molecular biology, genetics, and immunology. This research delineates how interaction dynamics between tumour cells and immune cells influence each other, contributing to our understanding of tumour progression and antitumour immune response. 

The Chudnovskiy laboratory's research in tumour immunology is directed at three pivotal questions. The first examines how tumour cells induce immune cell exhaustion, leading to a weakened response against the tumour. The second question investigates the evolution of tumour cells to evade the immune system's cytotoxic cells. The third investigates how tumours manipulate antigen presentation to shift T cell responses from being immune-reactive to tolerant of tumour antigens.

Details of research projects currently being undertaken can be seen at: 

https://www.crick.ac.uk/research/labs/aleksey-chudnovskiy

Research techniques used in the laboratory include: We utilize immunological, genetic, genomic, molecular and synthetic biology techniques to study tumour immunology.

Key Responsibilities

The role of a Senior Laboratory Research Scientist in the Crick is diverse and rewarding. The role covers a wide range of different functions and allows for continuity of lab operations.

• Developing new techniques and protocols that are critical to the laboratory.
• Assisting the group leader with daily tasks.
• Engaging in and advancing a variety of scientific projects.
• Fostering collaboration with different laboratories within the Crick.
• Instructing both current and new lab members in general protocols and techniques that are commonly used in the lab.
• Drafting, executing, and revising Safety Assessments.
• Creating, implementing, and revising mouse protocols.
• Managing the care of complex genetically modified mouse colonies.
• Overseeing lab management.
• Sharing experimental results and discoveries both within and beyond the Crick. 

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council, Cancer Research UK, Wellcome, UCL, Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy. 

• If you are interested in applying for this role, please apply via our website.
• The closing date for applications is 15/11/24
• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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