PhD Studentship: Targeting Osteoclast-Tumour Interactions to Suppress Osteosarcoma Metastasis

For the past 30 years, survival rates in osteosarcoma (OS) patients have remained unchanged, partly due to the lack of knowledge on the mechanisms of metastasis. Preclinical and clinical evidence highlight that OS tumours may reside in the bone environment due to interactions with bone cell populations such as osteoclasts. Disrupting these interactions allows OS to spread to the lungs. In our prior study, we identified 'Migratory Bodies' (MBs) as a valuable laboratory model for studying OS metastasis. Osteoclast factors slow down MBs, but the drug zoledronic acid (used to treat osteoporosis) can counteract this effect, leading to pulmonary spread.

This project will use genetic engineering to unravel how OS spreads, with a particular focus on potential drug targets STAT3 and MMP9. Additionally, this project will examine OS metabolism and employ our unique chick model to enhance our understanding of metastasis. This research holds promise for refining OS treatment strategies, incorporating insights into osteoclast interactions, with the ultimate goal of improving outcomes for patients. The project will be carried out in close collaboration with the research group of the Co-Supervisor (Dr Scott Roberts, Royal Veterinary College, London).

Studentship title: Targeting Osteoclast-Tumour Interactions to Suppress Osteosarcoma Metastasis

Sponsor: Hannah’s Willberry Wonder Pony

Qualification: PhD - Full time for 4 years

Eligibility: UK students

To study this course the applicant will need to meet the English Language requirements of IELTS 6.5 overall (with a minimum of 5.5 in all other sub-skills)

Location: Hendon, London and Camden, London

Mode of Study: Full-time

Funding: £20,069.25 plus £2000 London weighting allowance per annum

Academic staff involved in the project: Dr Helen Roberts (Middlesex University)  Dr Song Wen (Middlesex University)

Start date: 6th January 2025

Applicant requirements

Essential

• An undergraduate degree (1st or 2:1) in molecular biology/cell biology (or related discipline)
• Experience of undertaking a research project
• A high level of motivation, with the ability to work independently and as part of a multi-disciplinary team
• An academic record of excellence with good writing and communication skills

Desirable

• An MSc or MRes in molecular biology, tissue engineering or related discipline
• A strong background in cancer and/or musculoskeletal biology
• Experience in molecular biology and/or mammalian cell culture techniques
• Authorship on scientific publications

About Middlesex University

The student will be based in the Centre for Investigative and Diagnostic Oncology within the Faculty of Science and Technology at Middlesex University. This department focusses on a range of oncology-associated research including epigenetics, biomaterials, bioengineering, stem cell biology, nanoparticles, immuno-oncology and chemoresistance.

How to apply for the role

Please email the below to Dr Helen Roberts - h.roberts@mdx.ac.uk.

• Up to date Curriculum Vitae
• Personal Statement to demonstrate why you are interested in this PhD position. You should ensure you mention the title of the studentship when you submit your application.

For further information about Research Studentships visit the applicant portal: https://www.mdx.ac.uk/study-with-us/postgraduate/research-studentships

Contact Person

If you are interested in applying, please contact Dr Helen Roberts – Director of Programmes Natural Science/Associate Professor in Skeletal Cancer Research h.roberts@mdx.ac.uk.

Application deadline: 5th November 2024

Interviews: November 2024

Apply link: https://www.mdx.ac.uk/study/postgraduate/research-studentships/phd-studentship-targeting-osteoclast-tumour-interactions-to-suppress-osteosarcoma-metastasis/

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