Postdoctoral Researcher - Protein Biochemist and Physicist

We have an exciting opportunity to recruit a Postdoctoral Researcher to join the Centre for Medicines Discovery (CMD) and its Biochemistry and Biophysics Group led by Dr. Oleg Fedorov. You will work alongside structural biologists and molecular biologists in the CMD and to discover novel therapeutic approaches to various human diseases.

CMD mission is to de-risk novel therapeutic approaches and discover novel agents fit for further discovery investment. Consequently, we work closely with pharma and biotech companies and operate industry-style project teams to deliver our target validation and translational goals.

This post provides an opportunity to work on a variety of projects in all biology areas in a uniquely collaborative academic department in which to work; the freedom and flexibility, offered by an academic research environment, in which to train and develop your initiatives and capabilities.

You will be responsible for developing biochemical, biophysical, and target engagement assays, and utilising them to identify and evaluate ligands for the proteins of interest. You will be executing bench-level experiments with the expectation of being able to write protocols, design experimental plans, develop new scientific techniques, and contribute and develop ideas for new research projects.  You will also be independently using and managing specialist scientific equipment in a laboratory environment, such as Echo (automated liquid handling), Pherastar plate readers, Biacore (SPR), ITC, Octet (BLI), RapidFire mass spectrometry (Agilent).

To be successful in this role, you will hold a PhD/DPhil (or be close to completion) in Biochemistry, Biophysics, Pharmacology, or other similar subject along with a background in protein biochemistry/enzymology with experience in the determination of drug mechanism of action and analysis of thermodynamics and kinetics. You will have previous experience of in vitro assay development including one or more of:  biochemical, biophysical assays, protein-protein interaction assays and/or cellular target engagement assays (e.g. HTRF, enzyme activity assays, BLI, SPR, mass spectrometry) and possess excellent interpersonal, oral, and written communication skills along with the ability to communicate well and to collaborate effectively within a dynamic team and matrix environment.

Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience.

This position is offered full time on a fixed term contract until 31 July 2026 and is funded by the Department.

Only applications received before 12 midday on Tuesday 5 November 2024 will be considered. Interviews to  be hold the week commencing 18 November 2024. Please quote 175445 on all correspondence.

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