Postdoctoral Fellow

Location: The Francis Crick Institute, Midland Road, London

Short summary

Dr Bishop is seeking a talented and motivated postdoc to study the function of the HIV Vpr protein during HIV infection. 

The successful applicant will investigate how Vpr impacts the cell and how this promotes viral replication. The project will initially focus on Vpr-induced DNA damage and the effects on chromatin, but all aspects of Vpr biology may be investigated. 

Postdoctoral Fellows are expected to lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and guide PhD students in their research. The ability to work in a team is essential. 

Dr Bishop’s laboratory focuses on the early, post-entry replication of retroviruses including HIV and MLV. She is interested in understanding the molecular events that occur when a retrovirus infects its target cell in order to fully understand retroviral replication and provide potential ways in which to manipulate these processes for the benfit of human health. Details of current research projects can be seen at:  https://www.crick.ac.uk/research/a-z-researchers/researchers-a-c/kate-bishop/. Her lab uses a wide range of research techniques including virological, biochemical and microscopy techniques and she collaborates closely with structural biologists.

The successful applicant will investigate the function and cellular targets of Vpr during HIV-1 replication, focusing initially on Vpr-induced DNA damage and how this promotes viral replication.

Key experience and competencies 

Essential

• PhD in virology, cell biology or molecular biology
• Good knowledge and understanding of retrovirology
• Expertise in molecular biology and biochemical techniques
• Expertise in cell culture and transfection
• Pro-active in innovation and problem solving
• Experience of experimental design
• Track record of writing papers as evidenced by publications or submitted manuscripts in referred journals 

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy. 

• If you are interested in applying for this role, please apply via our website.
• The closing date for applications is 04/11/2024
• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom. 

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