Postdoctoral Research Assistant

About the Role 

 

An excellent opportunity has arisen for a Post Doctoral Research Assistant to work under the direct supervision of Dr Paul Holloway at the Radcliffe Department of Medicine. The Holloway group focuses on developing new models of cerebrovascular disease, combining microfluidic techniques and iPSC technologies to provide insights into pathomechanisms in stroke and cerebral small vessel disease.

 

This project is a collaboration between the Holloway lab and the lab of Dr Alessandra Granata (University of Cambridge). The post is based at the University of Oxford John Radcliffe Hospital OX3 9DU and is offered on a full-time basis for 2 years.

 

The post holder will work on a project using patient derived iPSCs to explore the role of pericytes, astrocytes and endothelial cells in contributing to barrier dysfunction and extracellular matrix disruption in monogenic forms of cerebral small vessel disease. In this multidisciplinary project the post holder will use and develop advanced cell culture techniques to build microfluidic vessel on chip models to explore underlying disease mechanisms in vessel dysfunction.

 

About you 

 

You will require a relevant DPhil or be within 1 month of submission. Knowledge and experience with mammalian cell culture and basic molecular biology techniques including qPCR and immunocytochemistry is essential. Expertise in iPSC cell culture and differentiation, along with experience with using and developing microfluidic and organ on chip techniques is highly desirable. Experience with CAD and CFD modelling and microfluidic fabrication techniques using soft lithography would be advantageous. A proven track record of contributing to publications and presentations, along with the ability to generate new research ideas and secure funding, is essential. Excellent communication skills, including writing for publication and presenting research proposals and results, are also required.

 

About the Radcliffe Department of Medicine 

 

The Radcliffe Department of Medicine (RDM) within the Medical Sciences Division is one of the largest departments in the University of Oxford. RDM is a multi-disciplinary department which aims to tackle some of the world’s biggest health challenges by integrating innovative basic biology with cutting edge clinical research. Investigative Medicine is part of the Radcliffe Department of Medicine. We have staff based at the Weatherall Institute of Molecular Medicine and John Radcliffe Hospital sites.

 

Benefits of working 

 

As an employer, we genuinely care about our employees’ wellbeing and this is reflected in the range of benefits that we offer including: 

• An excellent contributory pension scheme
• 38 days annual leave
• A comprehensive range of childcare services
• Family leave schemes
• Cycle loan scheme
• Discounted bus travel and Season Ticket travel loans
• Membership to a variety of social and sports clubs  

See https://hr.admin.ox.ac.uk/staff-benefits for more information.

 

 

“Committed to equality and valuing diversity” 

 

The post is full-time and fixed-term for 2 years.

 

Applications for this vacancy are to be made online. You will be required to upload a supporting statement and CV as part of your online application. The supporting statement should include a cover letter and should also clearly describe how you meet each of the selection criteria listed in the job description. Click here for more information and advice on how to write an effective supporting statement.

 

Only applications received before 12:00 midday on 15/10/2024 will be considered.

 

Interviews are due to take place 21/10/2024. 

Type / Role:

Subject Area(s):

Location(s):