Location: | Bath |
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Salary: | £37,099 to £44,263 Grade 7, per annum |
Hours: | Part Time |
Contract Type: | Fixed-Term/Contract |
Placed On: | 27th June 2024 |
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Closes: | 16th July 2024 |
Job Ref: | ED11831 |
About the role
Promoting the regression of angiogenesis in the pathology of rheumatoid arthritis
Low oxygen (hypoxia) is a feature of arthritic joints, which leads to the growth of blood vessels (angiogenesis) into the joint cavity.
Angiogenesis, the process of new blood cell formation, is associated with the progression of rheumatoid arthritis (RA) through aiding the recruitment of immune cells, which enhances inflammation within the joint and supports the hyperplastic proliferation of the synovium and infiltrated inflammatory immune cells.
Most current RA therapies target the inflammatory response, and although these are effective, there are some patients who do not respond to these types of treatments.
Therefore, as inflammation and angiogenesis exist concomitantly, there is an urgent need to target angiogenesis in RA for therapeutic benefit.
This is an exciting opportunity to identify signalling pathways that regulate angiogenesis, in research groups led by Dr MacKenzie, Dr Bowler, Dr Tansley, and Prof Lindsay.
In this role, you will play a key role in establishing a vascularization cell culture model to study the effects of varying oxygen levels on angiogenesis in the context of an arthritic joint.
You will then utilise your cell culture, western blot and immunohistochemically expertise to elucidate the signalling pathways triggered by oxygen changes.
As a member of Research Staff at the University of Bath, you will be encouraged to take up a minimum of 10 days professional development pro rata per year"
We are seeking a talented postdoctoral research associate to join our team and contribute to a cutting-edge project investigating the role of oxygen in cellular signalling pathways in the context of rheumatoid arthritis & the regulation of angiogenesis.
This position would suit a candidate who has just completed their PhD in a relevant subject.
This is fixed-term research grant funded by the Bath Institute for Rheumatic Disease.
This is a part-time role.
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